PRODUCTS REVIEW - HERBOLOGIA HOLISTIC COSMETICS
1. HERBOLOGIA LIQUID CRYSTAL NATURAL SUPER ANTI-AGING PREMIUM DAY CREAM 50ml
💡DETAILS: Herbologia Liquid Crystal Day Cream introduces a new standard in wrinkle treatments with maximum strength powerful peptides and moisture-holding actives for a complete daily care of aging skin. It increases collagens I, III, IV, VII, XVII, fibronectin, hyaluronan, and laminin 5, and diminishes skin roughness and the depth and number of wrinkles. This cream is light and hydrating thanks to Hyaluronic Acid and Squalane which attract and hold moisture on the surface of the skin. Palmitoyl Tripeptide-38 and Syn-TC are peptides with a holistic action on multiple dermal components that promote skin rejuvenation and restoration, improving skin tone and firmness, moisture, and reducing wrinkles. Liquid Crystal Day Cream uses new technology in natural cream making, using a new olive oil based emulsifier which creates a liquid crystal structure within the cream mimicking the way our skin barrier is organized. As a result, the Liquid Crystal cream is much lighter and more absorbent than regular creams, and it will not dissolve skin lipids but restore and nurture the delicate balance of epidermis. Additionally, this cream features ceraminde liposomes, cholesterol, and natural oils Chilean Hazelnut Oil, Marakuja Oil, and Pomegranate Oil, which build and nourish the lipid barrier with a superior moisturizing effect. Green Tea Extract is packed with antioxidants that help to fight free radicals that age the skin and reduce the harmful effects of sun radiation and pollution. Vitamin C in its stable form as glyceryl ascorbate works in conjunction with Green Tea for a much stronger antioxidant potency. Liquid Crystal Day Cream is free of toxic or bioaccumulating ingredients. It is most compatible with the skin barrier, and it will rejuvenate and hydrate your skin and make it appear more youthful and healthy.
✅RATING: 10/10
🔴MY REVIEW: Have used so many brands and keep coming back to this one. The scent is light and the cream goes on very smooth. It moisturizes well, not too greasy on my skin as it absorbs well. It can give me a dewy look. Awesome for dry sensitive skin as well. Definitely would recommend.
2. HERBOLOGIA LIQUID CRYTAL NATURAL SUPER ANTI-AGING PREMIUM NIGHT CREAM 50ml
💡DETAILS: [Skin Types: All skin types] Liquid Crystal Natural Restructuring Night Cream for dehydrated skin is packed with restoring, rejuvenating, and hydrating actives for exceptional overnight therapy with a peptide complex, a higher squalane content, premium plant oils, herbal extracts, ceramides, and non-toxic plant based fragrance. The Night Cream features Syn®-Tacks, a combination of two peptides (Palmitoyl Dipeptide-5 Diaminobutyloyl Hydroxythreonine and Palmitoyl Dipeptide-6 Diaminohydroxybutyrate), at maximum concentration which benefit the skin in multiple ways: improve structural integrity; improve cellular communication; visibly tighten and lift saggy skin; reduce wrinkles; increase skin tone; nourish skin. Homeostatine is another anti-aging active. It is a complex of marine pentasaccharine and caesalpinia spinosa gum that creates a 3D hydrocolloidal matrix. Homeostatine reduces wrinkles by maintaining homeostasis in the skin, it reduces MMPs (matrix metalloproteinases or enzymes that break down proteins contributing to skin aging), and increases collagen, integrin and laminin V production. MCT oil, hyaluronic acid, squalane, ceramides, natural oils, and cholesterol supply all skin barrier lipids to restore, soothe, nourish, hydrate, and soften your skin to give it that needed overnight moisture. Olive Leaf Extract is one of the highest extracts in antioxidant content. Oleuropein and hydroxytyrosol are two very potent polyphenols that are known to improve skin texture and smoothness, and reduce wrinkles, sun damage, and irritation. Sea Buckthorn is a superfood from the Middle East that is rich in natural vitamins E, C, and A, minerals, and polyphenols that nourish and lighten the skin, soothing irritation and reducing fine lines and wrinkles.
✅RATING: 10/10
🔴MY REVIEW: I’ve only been using this for a month and there was an almost immediate difference in my skin. I love their products so much. They have never let me down. It really helped plump my face making me look years younger. Will definitely recommend and would even suggest to also try their full range of products.
3. HERBOLOGIA INGENUE NATURAL SUPER ANTI-WRINKLE EXFOLIATING PREMIUM CREAM 50ml
💡DETAILS: Skin types: normal to oily, combination, and dry skin. Ingenue Natural Anti-Wrinkle cream contains the maximum concentration of Allantoin (2%), a natural acid found in most organisms. Allantoin has a host of benefits for the skin: sloughs off dead skin cells, renewing the epidermal layer and improving the look of skin; reduces fine lines and wrinkles; improves the color of the skin; has mild lightening & anti-hyperpigmentation action; moisturizes skin; soothes irritation; tightens and firms the skin, making it appear younger. They found that it works synergystically with Palmitoyl Tripeptide-38, one of the most potent anti-aging peptides which targets multiple skin components such as collagens I, III, IV, fibronectin, hyaluronan, and laminin 5. As a result of the combined action of Allantoin and Palmitoyl Tripeptide-38, the skin looks dramatically younger, reducing the skin age by up to 10 years! Ingenue Natural Anti-Wrinkle Cream also contains high-end plant oils such as Argan, Borage, Chilean Hazelnut, and Maracuja Oils. Their combination contains the most complete fatty acid profile needed for mature skin health. These oils are extremely nourishing and yet are not greasy! In addition, they added ceramide liposomes, cholesterol, hyaluronic acid, and squalane for superior skin barrier therapy and hydration.
✅RATING: 10/10
🔴MY REVIEW: This product is awesome. Visible improvement in just a month. It really plumps up those tiny lines and makes my skin look brighter and healthier. To be honest, my skin looks better than it has looked in probably the last three years. Friends even notice the difference in my skin and asked what I was using. I’m incredibly impressed with this product and would recommend it to everyone. By the way, I have experienced no breakouts or redness.
4. HERBOLOGIA MYTHOS NATURAL SUPER ANTI-AGING EXPRESSION LINES SERUM 30ml
💡DETAILS: HERBOLOGIA MYTHOS EXPRESSION LINES SERUM is a luxurious hydrating serum with a comples of powerful peptides that target muscle contraction mechanism through multiple pathways. Palmitoyl Tripeptide-5 builds collagen and reduces fine lines and wrinkles. Turmeric extract aids the anti-aging effect by increasing blood circulation and fighting free radicals. It gives the serum a slight tingling effect.
✅RATING: 10/10
🔴MY REVIEW: I have been using it for nearly a month and am very pleased with the results so far. It has smoothed out my tiny lines and definitely firmed out my skin. It surely does what it says. I have researched a lot of serums and their ingredients. This one is absolutely one of the best. Overall, I find it keeps my aging face looking much less wrinkled than it was. Thank you so much for making these great products. Please don’t ever stop.
📌Disclaimer: I received these products for free in return for providing my honest and unbiased review. Please note that what may work for me, may not work for anyone else. Results may vary from person to person, so please take this into consideration if you decide to try those products.
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mechanism of cellular aging 在 運動營養師 楊承樺 Facebook 的最佳解答
好文分享,王醫師結論:
1. 胰島素阻抗是人體的一種保護機制,如果人體沒有胰島素阻抗,#心肌 受到的損害更大,你更「早死」。如果人體沒有胰島素阻抗,#骨骼肌 受到的損害更大,你 #活動會受限,你更「早死」。以長期的觀點來看,胰島素阻抗保護你的「心臟」,讓你能持續活下來,保住你的「骨骼肌」,希望你能多增加體能活動,降低所謂的 #熱量中毒狀態(Caloric intoxicated state)。
2. 糖尿病的治療的大方向除了藥物治療之外,#一定要配合生活型態的改變,#減少高熱量高精緻飲食,#少添加糖及 """#增加體能活動""" 等。
胰島素阻抗是人體的一種保護機制?
現代化社會中的人們由於飲食及生活型態的影響,罹患糖尿病的人口迄今不斷攀升,而目前有一些學者認為胰島素阻抗,從進化的角度來看原本是人類生存中的一種生理適應保護機制 。但在現代文明環境下(高熱量高精緻飲食及低體能活動等)這樣的機制被持續慢性的被激活,最終導致第II型糖尿病。
近年來有學者提出了關於II型糖尿病致病機制的新假設,就是所謂的熱量中毒(Caloric intoxication).
在目前的環境中,高熱量攝取,低體力活動和慢性壓力等,造成脂肪組織中多餘脂肪的儲存遠遠超過其儲存能力和脂質調節。然而脂肪儲存庫中的脂質過載,而導致脂肪細胞功能障礙及引發脂質溢出至週圍組織,造成整體的慢性發炎狀態。
然而,當營養熱量不再以安全的方式儲存時,就會造成多餘能量的異位儲存(Ectopic fat storage),特別是儲存在胰臟或肝臟中的內臟脂肪,這是在第II型糖尿病的發展中起著重要作用。
第II型糖尿病的特徵在於體循環中葡萄糖,脂質和游離脂肪酸的水平逐漸增加,其對體內的細胞和組織具有毒性作用,即所謂的醣脂毒性(Glucolipotoxicity):換言之,就是所謂的熱量中毒狀態(Caloric intoxicated state)。
重點來了,目前的研究認為人體產生胰島素阻抗是為了保護心肌細胞。心臟為了保護心肌細胞免於心肌細胞能量毒性損傷(Myocardial fuel toxicity),產生了胰島素阻抗,不要讓過多的能量進入心肌細胞,造成心臟損傷。簡單來說就是如果沒有胰島素阻抗,你也活不了了。
在誘導胰島素抗性的初期及中期,胰臟的β細胞通過增加胰島素產生來響應以將血糖維持在正常水平,這就是所謂的高胰島素血症(Hyperinsulinemia)。這使得身體能夠在不同特異性的器官組織之間分配能量,例如在脂肪組織中增加的相對胰島素效應和增加的能量儲存,同時心臟受到更好的保護。
我們可以看得出來這是身體的兩難,一方面增加胰島素阻抗一方面又增加更多胰島素的生產,這是為了心臟的防禦也增加了其他器官的負擔。
到了胰島素抗性的中晚期,就是所謂的胰島素分泌衰竭期,一旦進入這個階段,大多數的糖尿病患者都需要用胰島素治療來控制好血糖。
目前越來越多證據顯示致肥胖環境(高精緻飲食及低體能活動等)( Obesogenic environment),基因及表觀基因(epigenetics),引發胰島β細胞的高反應性(hyper-responsiveness Islet β-cell) 而導致高胰島素血症(Hyperinsulinaemia)。這也是造成「胰島素抗性」及「代謝症候群」主要驅動因素。圖二
而代謝症候群或高胰島素血症(Hyperinsulinaemia)也引發了這些下游的慢性疾病,例如:第II型糖尿病(T2D),心血管疾病(CVD),非酒精性脂肪性肝病/非酒精性脂肪性肝炎(NAFLD / NASH)和多囊卵巢綜合徵(PCOS)等。
這裡有個小故事.
你可以把「人體」想像成一個「小宇宙」,人體的每顆「細胞」就是小宇宙中的「星球」。然而在小宇宙星球上的「人口」就等於身體中的「熱量」(葡萄糖,脂質和游離脂肪酸)。當小宇宙中或星球的人口(熱量)不斷的增加,這等同於人體細胞熱量中毒狀態(Caloric intoxicated state).在這種情況下,細胞(星球)將面臨滅亡。
人體(宇宙)為了存活,起動了「薩諾斯(Thanos)模式」,就是所謂的「胰島素抗性」。這讓宇宙中的星球(細胞)中人口(熱量)減半,來減緩宇宙或星球的毀滅。
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以下將更進一步的討論糖尿病治療的概念框架,主要內容來自以下這篇論文。個人認為非常值得參考。
Insulin resistance and insulin hypersecretion in the metabolic syndrome and type 2 diabetes:Time for a conceptual framework shift
https://doi.org/10.1177/1479164119827611
目前有學者把糖尿病分成五種類型,包含嚴重自體免疫 (SAID),嚴重胰島素缺乏 (SIDD),嚴重胰島素阻抗 (SIRD),輕微肥胖相關 (MOD)及輕微年齡相關 (MARD)。
以下這篇論文將糖尿病更簡單的分成兩種。
1. 未治療的高胰島素血症第II型糖尿病(untreated type 2 diabetes (T2D) with hyperinsulinaemic diabetes)。
2. 未治療的低胰島素血症第II型糖尿病(untreated hypoinsulinaemic T2D)。
而我們人體中的對胰島素的反應也可以分成兩種細胞。
1. 胰島素反應細胞(insulin-responsive cells): 心肌細胞和骨骼肌細等。
2. 胰島素無反應細胞(insulin non-responsive cells): 內皮細(Endothelial cells),大小血管等。
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(A) 未治療的高胰島素血症第II型糖尿病(untreated type 2 diabetes (T2D) with hyperinsulinaemic diabetes)。
在(a)左圖我們可以觀察到胰島素抗性(IR)保護胰島素反應細胞,例如心肌細胞和骨骼肌細胞免受營養熱量過載,不要讓過多的能量進入心肌細胞,造成心臟損傷。 然而,人體的高血糖對胰島素無反應的細胞如內皮細胞(大小血管等)不受保護作用,長期下來就會導致心血管疾病、腦血管疾病、視網膜病變、神經病變及腎病變等慢性疾病。
而(a)中圖的情況是通過高劑量胰島素治療,來降低胰島素抗性(IR).而這種情況可以「降低胰島素無反應細胞」(insulin non-responsive cells) 損傷,但「胰島素反應細胞」(insulin-responsive cells)就無法受到保護,心肌細胞就會受到營養熱量過載的影響,引發所謂的代謝心肌病變(metabolic cardiomyopathy)。這是人體的兩難,這或許是為什麼一些研究認為非常嚴格控制血糖,反而有較高死亡率。
Effects of intensive glucose lowering in type 2 diabetes.
N Engl J Med 2008; 358: 2545 – 59.
Effects of intensive glucose lowering in the management of patients with type 2 diabetes mellitus in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial.
Circulation 2010; 122: 844 – 6
(a)右圖是一般認為最好的情況.
1. 透過減少葡萄糖進入血液: 減少高熱量高精緻飲食,低糖飲食,α-葡萄糖苷酶抑製劑(α-glucosidase inhibitors)及減肥手術等。
2. 透過一些途徑讓葡萄糖從血液中清除: 生活型態改變,增加體能活動,運動,SGLT2抑製劑促進尿液葡萄糖排出和激活棕色脂肪組織等)。
這種雙管齊下的作法,可以避免所有胰島素反應或無反應細胞的組織損傷,也可以得到最佳的血糖控制狀態。
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(B) 未治療的低胰島素血症第II型糖尿病(untreated hypoinsulinaemic T2D)。
在(b)左圖發生對低胰島素的飢餓反應下,其中游離脂肪酸(FFA)從脂肪組織釋放增加,肝酮體產生增加;心肌細胞和骨骼肌細胞缺乏葡萄糖,轉而使用FFA和酮體作為能量.然而內皮細胞未受到高血糖的保護。
(b)中圖,在這種情況下,「胰島素治療」將防止飢餓反應(starvation response),使胰島素反應細胞(insulin-responsive cells): 心肌細胞和骨骼肌細等營養狀態正常化並防止內皮細(Endothelial cells)的葡萄糖毒性。
(b)右圖,運用嚴格降低血中葡萄糖降低的方法,即從細胞中卸載葡萄糖(例如通過非常低的碳水化合物飲食或禁食)以及血液中的葡萄糖清除(例如SGLT2抑製劑)將加劇低胰島素血症T2D中的飢餓反應並誘導血糖正常的酮症酸中毒(Euglycaemic ketoacidosis)。
我個人認為生酮飲食或極低碳飲食在「低胰島素血症第II型糖尿病」這一類的病人還是會有風險的,特別是這類的患者實行生酮飲食又加上斷食,或者有加上SGLT2抑製劑等藥物,會引發酮酸中毒的機率就會增加。以下已經有一些論文或個案的發表.
Life-threatening ketoacidosis in patients with type 2 diabetes on LCHF diet
Bonikowska K, et al. Lakartidningen. 2018
Ketoacidosis associated with low-carbohydrate diet in a non-diabetic lactating woman: a case report
doi: 10.1186/s13256-015-0709-2
EUGLYCEMIC DIABETIC KETOACIDOSIS WITH SGLT2 INHIBITOR USE IN A PATIENT ON THE ATKINS DIET: A UNIQUE PRESENTATION OF A KNOWN SIDE EFFECT
https://doi.org/10.4158/EP171860.CR
結論:
1. 胰島素阻抗是人體的一種保護機制,如果人體沒有胰島素阻抗,心肌受到的損害更大,你更「早死」。如果人體沒有胰島素阻抗,骨骼肌到的損害更大,你活動會受限,你更「早死」。以長期的觀點來看,胰島素阻抗保護你的「心臟」,讓你能持續活下來,保住你的「骨骼肌」,希望你能多增加體能活動,降低所謂的熱量中毒狀態(Caloric intoxicated state)。
2. 糖尿病的治療的大方向除了藥物治療之外,一定要配合生活型態的改變,減少高熱量高精緻飲食,少添加糖及增加體能活動等。
3. 糖尿病患者實行任何飲食法最好能夠和臨床醫師討論,進一步減少一些沒有必要的風險。
#胰島素阻抗
#高胰島素血症
#糖尿病
參考資料:
Insulin resistance and insulin hypersecretion in the metabolic
syndrome and type 2 diabetes:Time for a conceptual framework shift
https://doi.org/10.1177/1479164119827611
Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes
doi: 10.2337/db14-0694
Insulin resistance is a cellular antioxidant defense mechanism
doi: 10.1073/pnas.0902380106
Insulin Resistance and Aging: A Cause or a Protective Response?
doi:10.1093/gerona/gls145.
Insulin resistance: An adaptive mechanism becomes maladaptive in the current environment — An evolutionary perspective
https://doi.org/10.1016/j.metabol.2012.11.004
Insulin resistance protects the heart from fuel overload in dysregulated metabolic states
doi: 10.1152/ajpheart.00854.2012