關於 brca ，我們在網路上蒐集到這些相關的討論、資訊與評價

#11. ACTBRCA® 貝癌檢™癌症基因檢測

而BRCA基因在這類型基因中尤其重要，若發生基因變異導致蛋白質功能喪失，DSB將無法正確修復，就發生癌變。 PARP為一種DNA修復酶，負責DNA雙股螺旋中的單股DNA斷裂修復( ...

#12. MH BRCA系統-精準預測乳癌基因突變對PARP抑制劑的療效

然而，若BRCA 基因發生突變，則可能導致罹患乳癌、卵巢癌、攝護腺癌。統計發現，具有家族遺傳病史的乳癌患者中，約有20-25% 都帶有 BRCA 突變，而所有 ...

#13. Methylation not a frequent "second hit" in tumors with germline ...

The relationship between BRCA LOH and BRCA promoter methylation has not been well characterized in tumors from BRCA germline mutation carriers. The goal of this ...

#14. BRCA Genetic Test: MedlinePlus Medical Test

A BRCA test is a blood test that checks to see if you have a genetic mutation that may increase your risk for breast and ovarian cancer.

#15. BRCA Gene Mutations | Bring Your Brave | CDC

Why BRCA Gene Mutations Matter. Not every woman who has a BRCA1 or BRCA2 gene mutation will get breast or ovarian cancer, but having a gene mutation puts you at ...

#16. Oncomine BRCA Research Assay | Thermo Fisher Scientific

The Oncomine BRCA Research Assay enables the detection of BRCA1/2 somatic mutations in FFPE tissue and germline mutations in whole blood.

#17. BRCA Exchange

The BRCA Exchange aims to advance our understanding of the genetic basis of breast, ovarian, pancreatic and other cancers by pooling data on BRCA1/2 genetic ...

#18. 精準醫療首部曲：BRCA 基因檢測乳癌與卵巢癌防治新契機

而近年研究發現TNBC 或卵巢癌病患若帶有BRCA1/BRCA2 突變基因，則可透過PARP (Poly ADP-ribose polymerase) 抑制劑來治療。 BRCA 突變癌症患者治療契機.

#19. BRCA1/ BRCA 2基因檢測- 臺中 - 台中榮總

BRCA1/ BRCA 2 mutation test. 可自費. 自費. 價格. 依本院定價. 參加認證. 是. 完成檢驗申請的說明. 由EHIS進行醫囑建立. 委託其他.

#20. BRCA1 and BRCA2 Genes - Memorial Sloan Kettering ...

If a person inherits a mutation in one of their BRCA genes, they have an increased risk for the associated cancers. It is important to understand that ...

#21. Center for BRCA and Related Genes

Heritable alterations (mutations) in BRCA1, BRCA2, and other BRCA-related DNA repair genes confer increased risk of multiple tumor types, particularly breast, ...

#22. Basser Center for BRCA - Abramson Cancer Center - Penn ...

Basser Center for BRCA. About BRCA1 and BRCA2. Both men and women who have a BRCA1 or BRCA2 gene mutation have an increased risk for developing certain ...

#23. Trends in Positive BRCA Test Results Among Older Women in ...

A gradual shift was observed as BRCA testing moved from being used mainly in women who already had a diagnosis of breast or ovarian cancer to ...

#24. 婦癌精準醫療新方向『基因檢測』 - 亞東醫院

BRCA 基因檢測(BRCA Gene Mutation Test) 正常的?BRCA?為抑癌基因之一，但若基因發生突變則易造成乳癌與卵巢癌的發生。BRCA1/2基因突變者，未來發生乳癌的風險 ...

#25. BRCA testing USPSTF guidelines - UpToDate

​ Recommendations from the United States Preventive Services Task Force on who should be offered genetic testing for BRCA mutations* ...

#26. BRCA mutation與PARP inhibitor在轉移性乳癌的治療／汪品瑜

將合成致死的概念應用在癌症患者，最知名的莫過於BRCA (Breast Cancer)基因突變與PARP (poly ADP-ribose polymerase)抑制劑(PARP inhibitor)的臨床 ...

#27. BRCA1 and BRCA2 Mutations | ACOG

How much do BRCA mutations increase the risk of breast cancer?

#28. BRCA 基因突變女性在接受風險降低手術(risk-reducing surgery ...

背景在一種BRCA 基因(BRCA1 DNA 修復相關或BRCA2 DNA 修復相關(BRCA1 或BRCA2) ) 錯誤(突變) 被檢測為陽性的女性更容易患乳癌和輸卵管-卵巢癌(tubo-ovarian cancer) ...

#29. BRCA-Related Cancer: Risk Assessment, Genetic Counseling

BRCA -Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing. August 20, 2019. Recommendations made by the USPSTF are independent of the ...

#30. 新藥介紹Olaparib (Lynparza®)

響著HR pathway的功能3，因此若BRCA gene產生突變，細胞則無法利用HR. 美國FDA在2014年核准. Lynparza(Olaparib)用於治療晚期卵巢癌. (Advanced ovarian cancer)之後 ...

#31. BRCA locus-specific loss of heterozygosity in germline ...

Tumors in BRCA1 and BRCA2 mutation carriers show high sensitivity to these agents in clinical trials. The sensitivity of BRCA-deficient cells to ...

#32. BRCA gene - Macmillan Cancer Support

BRCA is an abbreviation for breast cancer gene. BRCA1 and BRCA2 are two genes that can increase someone's chances of developing cancer if they mutate.

#33. Inherited Cancer Risk: BRCA Mutation - Johns Hopkins ...

Can you inherit risk for breast cancer? Sometimes. Everyone has two types of breast cancer (“BRCA”) genes in every cell of their body.

#34. Center for BRCA Research

Center for BRCA Research ... Scientists know that people who carry an inherited gene mutation, like BRCA1 or BRCA2, have an increased risk of developing cancer, ...

#35. Predictive genetic tests for cancer risk genes - NHS

BRCA genes are not the only cancer risk genes. Researchers recently identified more than 100 new gene variants associated with an increased risk of breast, ...

#36. Comprehensive BRCA Gene Testing Program | Mount Sinai

Learn about The Mount Sinai Health System's Comprehensive BRCA Program for Men and Women, providing genetic testing to determine your risk for cancer.

#37. BRCA Database - ARUP Scientific Resource for Research ...

BRCA1 and BRCA2 Mutation Databases. Through collaborations with the Huntsman Cancer Institute (HCI), and with the WHO International Agency for Research on ...

#38. BRCA Testing, Prophylactic Mastectomy, and ... - Aetna

Prophylactic mastectomy is considered experimental and investigational for men with BRCA mutations or family history of breast cancer because there is no ...

#39. New Recommendations for BRCA Testing: Should You Be ...

About 1 in 40 Ashkenazi Jewish women inherits one of the BRCA mutations, which are responsible for about 5% to 10% of breast cancer cases and 15 ...

#40. 10 Things to Know About BRCA Genes | Texas Oncology

While cancer patients are becoming increasingly aware of the BRCA genes, most don't understand their link to hereditary breast and ovarian cancers.

#41. Hereditary Breast and Ovarian Cancer | Cancer.Net

BRCA stands for BReast CAncer. A “mutation,” or harmful genetic change, in either BRCA1 or BRCA2 gives a woman an increased lifetime risk of developing ...

#42. BRCA gene: Testing, mutations, and more - Medical News ...

The breast cancer gene, or BRCA, informs a person's likelihood of getting cancer. People with a family history of breast cancer or BRCA gene ...

#43. Black & BRCA | Basser Center

Black & BRCA is a collaboration between the Basser Center for BRCA and its team of patient advocates, researchers and healthcare professionals to bring ...

#44. 同源重組的修系統

C, D1, D2, E, F, G, J, L和M（有一個尚未被發現），但是到目前為止，並沒有遺傳學的證據，顯示FA/BRCA基因的突變和肺癌的發生有關，這有可能是因為這套DNA修復機制對 ...

#45. BRCA Exchange as a global resource for variants in BRCA1 ...

The BRCA Challenge is a long-term data-sharing project initiated within the Global Alliance for Genomics and Health (GA4GH) to aggregate ...

#46. Role of BRCA Mutations in the Modulation of Response to ...

BRCA Mutations in Breast and Ovarian Cancers. BRCA1 and BRCA2 play a crucial role in maintaining genome integrity by repairing double-strand DNA ...

#47. BRCA Genes - 23andMe

BRCA stands for BReast CAncer gene. You can pronounce it “brah-kuh” or you can say “B” “R” “C” “A”. When we talk about BRCA1 and BRCA2, we are speaking the ...

#48. Reducing Cancer Risk When You Are BRCA-Positive

Top of the page Reducing Cancer Risk When You Are BRCA-Positive Topic Overview If you've found out that you have a BRCA gene change, you may be feeling ...

#49. BRCA Mutation - an overview | ScienceDirect Topics

Despite being derived from tumors of patients with hereditary breast cancer, the BRCA mutation signature has recently been shown to identify BRCA1, BRCA2, and ...

#50. FDA Approves First Drug Specifically for BRCA-mutated ...

The FDA also approved the BRACAnalysis CDx genetic test to identify people with breast cancer who have a BRCA gene mutation, and therefore ...

#51. Prevalence of germline BRCA mutations in HER2-negative ...

The global observational BREAKOUT study investigated germline BRCA mutation (gBRCAm) prevalence in a population of patients with human ...

#52. The Role of BRCA Mutations in Breast Cancer - Verywell Health

BRCA Genes Mutations. Mutations are genetic errors. BRCA gene mutations are autosomal dominant, meaning that having one copy of the abnormal ...

#53. Breast Cancer (BRCA) Gene Test

A breast cancer (BRCA) gene test is a blood test to check for changes (mutations) in genes called BRCA1 and BRCA2. This test can help you know your chance ...

#54. BRCA - Health Encyclopedia - URMC

The BRCA genes are the most common cause of gene-related breast and ovarian cancers. Why do I need this test? You may choose to have the BRCA test if you have a ...

#55. BRCA Genetic Testing & Your Family | beBRCAware

Find out how your family history and genetics could increase your cancer risk and read more about BRCA mutation testing.

#56. BRCA 遺傳檢驗及諮詢倫理準則

二、已患有乳癌或卵巢癌的病患，可建議其考慮進行BRCA 基因檢驗以確定病. 因，並可藉此推斷其家族是否具有罹病傾向，以利其家族成員及早防範。 三、若受檢者並無明顯乳癌或 ...

#57. Pregnancy After Breast Cancer in Patients With Germline ...

PURPOSEYoung women with germline BRCA mutations have unique reproductive challenges. Pregnancy after breast cancer does not increase the ...

#58. BRCA and Cancer - UCLA Health

Potentially harmful BRCA mutations also raise breast cancer risk for men. BRCA-related cancers develop differently than other breast cancers. They tend to ...

#59. Special Issue : BRCA Mutations and Cancer - MDPI

Special Issue "BRCA Mutations and Cancer". Special Issue Editors; Special Issue Information; Published Papers. A special issue of Cancers (ISSN 2072-6694).

#60. BRCA Genes and Breast Cancer - Columbia Surgery

Mutations in BRCA genes have been linked to an increased risk of developing breast and/or ovarian cancer. Learn about these genes, their connection to ...

#61. BRCA-associated Cancers: Role of Imaging in Screening ...

Harmful mutations of the BRCA tumor suppressor genes result in a greater lifetime risk for malignancy—breast and ovarian cancers in ...

#62. Breast Cancer (BRCA) Gene Test | Kaiser Permanente

A breast cancer (BRCA) gene test is a blood test to check for changes (mutations) in genes called BRCA1 and BRCA2. This test can help you know your chance ...

#63. BRCA Gene Mutations - Women | Susan G. Komen®

BRCA1 and BRCA2 (BReast CAncer genes 1 and 2) are the most well-known genes linked to breast cancer. This section provides information on BRCA1/2 inherited ...

#64. BRCA Plus Testing - Genomics For Life

The BRCA Plus panel is an extended panel looking at both the BRCA1 & BRCA2 tumor suppressor genes, as well as 9 other genes commonly involved in breast and ...

#65. BRCA gene | Health Navigator New Zealand

BRCA stands for BReast CAncer. We all carry the two BRCA genes, BRCA1 and BRCA2. These genes produce tumour suppressor proteins that repair ...

#66. Breast Cancer (BRCA) Gene Test | HealthLink BC

Discusses BRCA gene test to check chances of breast cancer if your family or personal history shows a high chance for this cancer. Covers a woman's risk of ...

#67. BRCA Mutation Carriers and Other Breast/Ovarian Hereditary ...

Prevention and Screening in BRCA Mutation Carriers and Other Breast/Ovarian Hereditary Cancer Syndromes: ESMO Clinical Practice Guidelines.

#68. BRCA and your cancer risk: What you need to know

Get the facts about the BRCA gene mutation, which is linked to a higher risk for breast cancer and other cancers.

#69. BRCA1 and BRCA2 for men - Oxford University Hospitals

The implications for men who carry a BRCA gene alteration depends on whether the alteration is in BRCA1 or BRCA2. Men who carry a BRCA1 gene alteration, may ...

#70. GeneRead QIAact BRCA 1/2 Panel - QIAGEN

GeneRead QIAact BRCA 1/2 Panel. For breast and ovarian cancer insights from FFPE samples on the GeneReader NGS System. Features. Full coverage: ...

#71. BRCA-P | Breast Cancer Trials

BRCA -P is an international breast cancer prevention clinical trial which will enrol 2918 patients. It is open to women with a confirmed BRCA1 gene mutation ...

#72. 遺傳性乳癌/卵巢癌BRCA基因檢測

遺傳性乳癌/卵巢癌BRCA基因檢測 · 1. 家族中罹患乳癌或卵巢癌的人數在兩人以上。 · 2. 近親中被診斷出早發性乳癌(45歲以下)。 · 3. 家族中同一人具有多發性乳癌（發病的部位或 ...

#73. AmpliSeq for Illumina BRCA Panel | Assess all exons of ...

The AmpliSeq for Illumina BRCA Panel is a targeted resequencing assay for research of somatic and germline variants across BRCA1 and BRCA2 genes.

#74. What Are BRCA Genes? Your Genetic Risk for Breast Cancer

BRCA is known as the breast cancer gene. Learn about BRAC1 and BRAC2, and the chances you may have of developing breast cancer.

#75. BRCA: The Breast Cancer Gene

The name “BRCA” is an abbreviation for “BReast CAncer gene.” BRCA1 and BRCA2 are two different genes that have been found to impact a person's chances of ...

#76. BRCA Germline I (gDNA) - Horizon Discovery

BRCA Germline I (gDNA) · Analyze the specificity and specificity of your assay · Optimize and validate new cancer panels and routinely monitor the performance of ...

#77. Breast Cancer and Genetic Testing - WebMD

Usually, BRCA genes help prevent cancer by fixing DNA damage that can lead to cancers and tumors. They also make proteins that help stop ...

#78. Adjuvant Olaparib for Patients with BRCA1- or BRCA2 ... - NEJM

BRCA mutation data reflect central Myriad testing results only. The CPS+EG score is a staging system for disease-specific survival among ...

#79. Inherited Risk: The BRCA Gene Explained - Drugs.com

The BRCA gene test is increasingly considered as an option for women at high risk for inherited breast cancer. Learn if you may need this test, ...

#80. Germline BRCA mutation and outcome in young-onset breast ...

The primary outcome was overall survival for all BRCA1 or BRCA2 mutation carriers (BRCA-positive) versus all non-carriers (BRCA-negative) at ...

#81. 5 Things You May Not Know About Being BRCA-Positive

Having a BRCA gene mutation doesn't mean you're powerless in the face of cancer.

#82. Understanding Hereditary Breast & Ovarian Cancer

BRCA is an abbreviation for breast cancer. BRCA1 and BRCA2 were the first two genes discovered to be responsible for some hereditary breast cancer and some ...

#83. Breast Cancer (BRCA) Gene Test | Cigna

A breast cancer (BRCA) gene test is a blood test to check for changes (mutations) in genes called BRCA1 and BRCA2. This test can help you know your chance ...

#84. Prevention and screening in BRCA mutation carriers and ...

Prevention and screening in BRCA mutation carriers and other breast/ovarian hereditary cancer syndromes: ESMO Clinical Practice Guidelines for cancer prevention ...

#85. BRCA 1 and 2--A Genetic Link to Familial Breast and Ovarian ...

Female carriers of germline BRCA1 mutations have a lifetime risk of breast cancer exceeding 80% and of ovarian cancer approaching 60%.

#86. Genetic testing for BRCA mutations - The Health Policy ...

Genetic testing for BRCA mutations. Genetic mutations in the BRCA1 and BRCA2 genes can significantly increase the risk of some cancers, but many people across ...

#87. Products & Services | BRACAnalysis - Myriad Genetics

BRCA mutations are responsible for the majority of hereditary breast and ovarian cancers. People with a mutation in either the BRCA1 or BRCA2 gene have ...

#88. Clinical Significance of Germline BRCA Mutations

These genes are called BRCA --for breast cancer. If you have a mutation in these genes special actions may be needed. For a person with a known mutation, ...

#89. BRCA Genes: The Role in Genome Stability, Cancer ...

BRCA genes, BRCA proteins and their clinical relevance. Tumor suppressor genes BRCA1 and BRCA2 were first linked to the breast and ovarian cancer susceptibility ...

#90. What is the Difference Between BRCA1 and BRCA2?

If I Have a BRCA Gene Mutation, Will I Get Cancer? “A BRCA mutation increases the risk of getting certain types of cancers,” Clayback says. “ ...

#91. BRCA1 & BRCA2 Testing to Predict Breast Cancer Risk

Learn more about BRCA1 & BRCA2 genetic testing. Breastcancer.org can help you connect with others who've tested positive.

#92. TransIT-BrCa Transfection Reagent - Mirus Bio

TransIT-BrCa Transfection Reagent provides superior DNA transfection of breast cancer cell types.

#93. Risk Assessment, Genetic Counseling, and Genetic Testing ...

Interventions in women who are BRCA mutation carriers include earlier, more frequent, or intensive cancer screening; risk-reducing medications ( ...

#94. 5 Things to Know about BRCA Mutations and Pancreatic Cancer

BRCA proteins impact cells' ability to repair DNA damage. The BRCA genes (BRCA1 and BRCA2) are tumor suppressor genes, which means that they ...

#95. 哪些癌症需要考慮BRCA基因檢測?

對於BRCA基因突變，目前已經有相應的標靶藥物PARP抑制劑上市，例如:olaparib(lypaza)、rucaparib(rubraca)、niraparib(Zejula)，讓變種的BRCA基因 ...

#96. BRCA Gene and Prostate Cancer | ZERO

What the BRCA Gene Means for Men and Families. Many of us have heard of the BRCA1 and BRCA2 genes (short for BReast CAncer genes 1 and 2) since they are the ...