你知道死侍夾斷手🖐,為什麼可以長出一模一樣的組織嗎?但有時候也可能長歪?
__________
本院細胞與個體生物學研究所陳振輝助研究員及其研究團隊的最新研究成果發現,經由調控特定基因的活性,可以 #改寫再生記憶。當「再生記憶」受到影響後,斑馬魚再生的新尾鰭可以出現不同的大小和形狀。
⭐這是科學家首次證實再生記憶可以被改寫,此基礎研究的發現有機會幫助「再生醫學」的發展。
陳振輝帶領研究團隊透過大規模隨機基因突變的方法,發現「再生記憶」受到影響的斑馬魚🐟。接著經由高解析度的基因定位分析和遺傳學的互補測試,找到再生記憶受損的斑馬魚其突變點所在的位置。
此突變點位在一個特定的基因「DNA聚合酶阿爾法次單元2(DNA polymerase alpha subunit 2, pola2)」。此基因的活性對細胞遺傳物質的複製分裂有直接的影響。實驗發現,藉由調控pola2的活性,可以有效改寫再生記憶。使成年斑馬魚在受傷後,再生出縮小版的尾鰭或是魚鱗,且被改寫後的再生記憶可以長期穩定存在,控制往後受傷後新生組織的大小與形狀。
#細生所 #陳振輝 #再生記憶 #斑馬魚 #首次證實
__________
From a chemical mutagenesis screen, a research team led by Dr. Chen-Hui Chen at the Institute of Cellular and Organismic Biology, Academia Sinica (Taiwan) accidentally identified a novel zebrafish mutant with defects in positional memory.
They found the mutation can cause tailfins to regenerate with high variability in sizes and shapes. Based on high-resolution genetic mapping and complementation assays, they determined DNA polymerase alpha subunit 2 (pola2) is the mutated gene. The gene activity has a direct impact on blastemal proliferation and size. Through manipulating pola2 activity, they developed an approach to effectively rewrite positional memory. The new memory is able to direct growth of tailfin and scales, even after repetitive injuries.
Through collaboration with Drs. Jr-Kai Yu and Yi-Hsien Su at the Institute of Cellular and Organismic Biology, they found similar effects upon transient pharmacological disruption of progenitor cell proliferation after head or tail amputation in amphioxus and annelids. There findings suggest that the regulatory mechanisms identified in this study may be evolutionarily conserved across vertebrate and invertebrate species.
__________
📌期刊論文〈Genetic reprogramming of positional memory in a regenerating appendage〉連結:https://www.cell.com/current-biology/fulltext/S0960-9822(19)31378-8
📌「再生」也可能長歪? 科學界首度證實:動物的再生記憶可被改寫
https://newsletter.sinica.edu.tw/20191128f03/
📌Memorizing regeneration
https://www.sinica.edu.tw/en/news/6415
_________
【媒體報導】
[中央社]再生記憶可被改寫 中研院發現關鍵調控基因
https://www.cna.com.tw/news/ahel/201911280069.aspx
[中國時報]中研院研究證實 動物再生記憶可被改寫
https://www.chinatimes.com/realtimenews/20191128002534-260405
[聯合報]破除250年假說 中研院發現生物組織的再生記憶可改變
https://udn.com/news/story/7270/4192416
[自由時報]調控特定基因活性 再生記憶可改寫
https://news.ltn.com.tw/news/life/paper/1335323
[國語日報]中研院新發現 調控關鍵基因 可改寫動物再生記憶
https://www.mdnkids.com/news/?Serial_NO=114369
同時也有10000部Youtube影片,追蹤數超過2,910的網紅コバにゃんチャンネル,也在其Youtube影片中提到,...
「transient current」的推薦目錄:
- 關於transient current 在 中央研究院 Academia Sinica Facebook 的最讚貼文
- 關於transient current 在 中央研究院 Academia Sinica Facebook 的精選貼文
- 關於transient current 在 蕭叔叔英式英文學會 Uncle Siu's British English Club Facebook 的最佳貼文
- 關於transient current 在 コバにゃんチャンネル Youtube 的最佳貼文
- 關於transient current 在 大象中醫 Youtube 的最讚貼文
- 關於transient current 在 大象中醫 Youtube 的精選貼文
- 關於transient current 在 What is transient current? ||alternating current// - YouTube 的評價
- 關於transient current 在 Wavelet Analysis and Transient Signal Processing ... 的評價
transient current 在 中央研究院 Academia Sinica Facebook 的精選貼文
你知道死侍夾斷手🖐,為什麼可以長出一模一樣的組織嗎?但有時候也可能長歪?
__________
本院細胞與個體生物學研究所陳振輝助研究員及其研究團隊的最新研究成果發現,經由調控特定基因的活性,可以 #改寫再生記憶。當「再生記憶」受到影響後,斑馬魚再生的新尾鰭可以出現不同的大小和形狀。
⭐這是科學家首次證實再生記憶可以被改寫,此基礎研究的發現有機會幫助「再生醫學」的發展。
陳振輝帶領研究團隊透過大規模隨機基因突變的方法,發現「再生記憶」受到影響的斑馬魚🐟。接著經由高解析度的基因定位分析和遺傳學的互補測試,找到再生記憶受損的斑馬魚其突變點所在的位置。
此突變點位在一個特定的基因「DNA聚合酶阿爾法次單元2(DNA polymerase alpha subunit 2, pola2)」。此基因的活性對細胞遺傳物質的複製分裂有直接的影響。實驗發現,藉由調控pola2的活性,可以有效改寫再生記憶。使成年斑馬魚在受傷後,再生出縮小版的尾鰭或是魚鱗,且被改寫後的再生記憶可以長期穩定存在,控制往後受傷後新生組織的大小與形狀。
#細生所 #陳振輝 #再生記憶 #斑馬魚 #首次證實
__________
From a chemical mutagenesis screen, a research team led by Dr. Chen-Hui Chen at the Institute of Cellular and Organismic Biology, Academia Sinica (Taiwan) accidentally identified a novel zebrafish mutant with defects in positional memory.
They found the mutation can cause tailfins to regenerate with high variability in sizes and shapes. Based on high-resolution genetic mapping and complementation assays, they determined DNA polymerase alpha subunit 2 (pola2) is the mutated gene. The gene activity has a direct impact on blastemal proliferation and size. Through manipulating pola2 activity, they developed an approach to effectively rewrite positional memory. The new memory is able to direct growth of tailfin and scales, even after repetitive injuries.
Through collaboration with Drs. Jr-Kai Yu and Yi-Hsien Su at the Institute of Cellular and Organismic Biology, they found similar effects upon transient pharmacological disruption of progenitor cell proliferation after head or tail amputation in amphioxus and annelids. There findings suggest that the regulatory mechanisms identified in this study may be evolutionarily conserved across vertebrate and invertebrate species.
__________
📌期刊論文〈Genetic reprogramming of positional memory in a regenerating appendage〉連結:https://www.cell.com/current-biology/…/S0960-9822(19)31378-8
📌「再生」也可能長歪? 科學界首度證實:動物的再生記憶可被改寫
https://newsletter.sinica.edu.tw/20191128f03/
📌Memorizing regeneration
https://www.sinica.edu.tw/en/news/6415
_________
【媒體報導】
[中央社]再生記憶可被改寫 中研院發現關鍵調控基因
https://www.cna.com.tw/news/ahel/201911280069.aspx
[中國時報]中研院研究證實 動物再生記憶可被改寫
https://www.chinatimes.com/realtimene…/20191128002534-260405
[聯合報]破除250年假說 中研院發現生物組織的再生記憶可改變
https://udn.com/news/story/7270/4192416
[自由時報]調控特定基因活性 再生記憶可改寫
https://news.ltn.com.tw/news/life/paper/1335323
[國語日報]中研院新發現 調控關鍵基因 可改寫動物再生記憶
https://www.mdnkids.com/news/?Serial_NO=114369
transient current 在 蕭叔叔英式英文學會 Uncle Siu's British English Club Facebook 的最佳貼文
I dropped my favourite glass today. And I spent fifteen minutes gazing at the broken pieces.
To my surprise, the glass, in its current, broken form, inspires more fondness and admiration in me, than when it was intact. To me, you are now more beautiful, more perfect.
I spent the next ten minutes recording its transient beauty in the form of a photograph.
That was the most peaceful thirty minutes I’ve ever spent in my life. The broken glass was the most beautiful thing I’ve beheld. And the clink at the moment of impact was the most enchanting sound.
Things that appear broken now may not be as bad as you imagine.
Maybe, the most horrendous thing is just around the corner.
Maybe, just maybe, the most horrendous thing, is me.
I think I‘ve got the answer.
感性叔叔
#蕭叔叔英文抽水站
#潮文
Credit: 充滿藝術感的原圖來自周柏豪先生
transient current 在 コバにゃんチャンネル Youtube 的最佳貼文
transient current 在 大象中醫 Youtube 的最讚貼文
transient current 在 大象中醫 Youtube 的精選貼文
transient current 在 Wavelet Analysis and Transient Signal Processing ... 的美食出口停車場
The transient component of the ground current is u t t / 0 i i i L e t I e Lm L dos Cos Los . . . sin cos 00 0 (9.16) In normal conditions, ω0/ω is great. ... <看更多>
transient current 在 What is transient current? ||alternating current// - YouTube 的美食出口停車場
Alternating Current. What is transient current ? ||alternating current// ... Transient Analysis: Behaviour of Basic Circuit Elements. ... <看更多>