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t cell lymphoma 在史丹福狂想曲 Facebook 的最佳解答

2021-09-14 20:40:37 有 34 人按讚

一位50歲，有吸煙及飲酒習慣的男士因發燒、鼻塞及口腔潰瘍而求醫。口腔檢查顯示病人近門牙的地方出現牙肉及硬顎（hard palate）潰瘍，潰瘍有不規則的邊界。活組織檢查顯示病人患上結外鼻腔型NK/T細胞淋巴瘤（Extranodal NK/T-cell lymphoma, nasal type）。

結外鼻腔型NK/T細胞淋巴瘤是一種惡名昭彰的淋巴癌，在亞洲地區特別常見。它由愛潑斯坦-巴爾病毒（Epstein-Barr virus）令到NK/T細胞異常地增生引起。顧名思義，這種淋巴癌大多影響鼻腔部分，可引起鼻中隔穿孔、硬齶穿孔、鼻樑洞穿性損傷等病徵。其他病徵包括發燒、肝脾腫大、血細胞減少等。治療的方案包括放射治療及化療（大多使用包含asparaginase的化療組合）。

圖片及個未取自以下刊登在《新英格蘭醫學期刊》（New England Journal of Medicine）的案例報告：

https://www.nejm.org/doi/full/10.1056/NEJMicm2100505?fbclid=IwAR280IBfKeRlOO20CGI75meAxatSJs20u0wevFBQjx

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t cell lymphoma 在史丹福狂想曲 Facebook 的最佳解答

By 史丹福狂想曲

2021-09-07 20:20:22 有 44 人按讚

揭曉昨天問題的答案。乳房重建或隆乳手術可能與一種名為乳房植入物相關間變性大細胞淋巴癌（Breast implant associated anaplastic large cell lymphoma，簡稱BIA-ALCL）的血液癌症相關。

BIA-ALCL是一種罕見的T細胞淋巴癌，是一種在植入物周圍形成的莢膜（capsule）組織出現的惡性腫瘤。約每50萬至300萬位有乳房植入物的女士才有一位會患上這種罕見的淋巴癌。BIA-ALCL的症狀包括腫脹、乳房形狀變化、不對稱、疼痛、腫塊等。雖然醫學界懷疑BIA-ALCL與乳房植入物相關，但暫時未有正式的科學研究顯示到兩者有直接關係。

在形態上，BIA-ALCL與ALK陰性間變性大細胞淋巴癌（ALK negative anaplastic large cell lymphoma）相同，並且兩者都呈CD30陽性。

BIA-ALCL的患者需要接受手術去移除乳房植入物和切除周圍的莢膜。他們在手術後一般都有良好的預後（prognosis），中位存活期達12年。

下圖取自《人類病理學：病理報告》(Human Pathology：Case Reports）的案例報告，顯示了BIA-ALCL的解剖病理檢查圖片。有興趣的朋友可以參考：

https://www.sciencedirect.com/science/article/pii/S2214330019300938

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t cell lymphoma 在 Facebook 的最佳貼文

2021-08-25 09:44:55 有 59 人按讚

【藥事知多D】一物兩用：維生素A酸

說到維生素A酸(Retinoic Acid)（俗稱「A酸」），很多人便會聯想到暗瘡藥，例如維A酸(Tretinoin)、異維A酸(Isotretinoin)。

對，A酸這類藥的其中一個用途，便是暗瘡。

不說不知道，A酸這類藥原來還有一種鮮為人知的用途……

這便是……

停！在揭曉答案前，藥罐子首先不妨在這裡簡單分享一下A酸的作用原理吧！

A酸這門派主要在跟維生素A酸受體(Retinoic Acid Receptors, RARs)、維生素A酸X受體(Retinoid X Receptors, RXRs)這兩類受體結合，然後這些受體便會充當轉錄因子(Transcription Factor)，調控基因的轉錄(Transcription)，從而控制細胞凋亡(Apoptosis)、細胞分化(Cell Differentiation)。[1]

其實這個作用原理便是一個提示了。

這話怎麼解？

因為這門派能夠影響細胞分化、細胞凋亡這兩個過程，所以有時候還可以用來治療癌症。

對，其中一些A酸還可以是一種化療藥，透過抑制細胞分化，干擾細胞周期，抑制癌細胞增殖或者誘發細胞凋亡，誘發體內癌細胞啟動細胞凋亡，導致癌細胞自動消失，達到殺滅癌細胞的效果。

這方面，常見的例子分別是Alitretinoin、Bexarotene。

一、Alitretinoin
　　
在藥理上，Alitretinoin是一種「百搭」致效劑，簡單說，便是一條百合匙，同時能夠跟各種不同的維生素A酸受體、維生素A酸X受體結合，治療癌症。
　　
暫時還是不太清楚具體的作用原理，只是知道Alitretinoin能夠治療卡波西氏肉瘤(Kaposi's Sarcoma)這種癌症。[1]

二、Bexarotene
　　
在藥理上，Bexarotene是一種選擇性維生素A酸X受體致效劑，顧名思義，主要跟維生素A酸X受體結合，治療癌症。
　　
暫時還是不太清楚具體的作用原理，只是知道Bexarotene能夠治療皮膚T細胞淋巴瘤(Cutaneous T-cell Lymphoma)這種癌症。[2]

最後因為A酸這門派能夠控制細胞分化、細胞凋亡，所以還可能會影響體內其他細胞分裂速度較快的正常細胞，例如胚胎(Embryo)，從而能夠干預胚胎進行正常的細胞分裂，干擾胎兒的正常發展。

這就是說，A酸大多擁有致畸性(Teratogenicity)，從而可能會增加孕婦誕下畸胎的風險。

（如欲了解更多用藥資訊，歡迎看看「小小藥罐子」網誌。）

💊💊💊💊💊💊💊
BLOG➡️http://pegashadraymak.blogspot.com/
IG➡️https://www.instagram.com/pegashadraymak/
YT➡️https://www.youtube.com/channel/UCQOMojMd6q7XnESMWwldPhQ

📕📕📕📕📕📕📕
著作➡️藥事知多D、用藥知多D、藥房事件簿、家居用藥攻略（各大書店有售）

Reference:
1. Sporn MB, Lippman SM. Chemoprevention of cancer. In: Kufe DW, Pollock PE, Weichselbaum RR, et al, eds. Cancer Medicine, 6th ed. Hamilton, Ontario, BC Decker, 2003:414-422.
2. Duvic M, Hymes K, Heald P, et al. Bexarotene is effective and safe for treatment of refractory advanced-state cutaneous T-cell lymphoma: multinational phase II-III trial results. J Clin Oncol. 2001;19:2456-2471.

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t cell lymphoma 在 [email protected] Youtube 的最佳貼文

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2020-02-19 15:15:57 有 54,460 人看過有 0 人喜歡

慢性骨髓性白血病不是絕症？－陳敏航血液及血液腫瘤科專科醫生＠FindDoc.com

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（一）慢性骨髓性白血病有什麼治療方法？ 00:06

（二）慢性骨髓性白血病是不是“絕症”？ 00:31

（三）TKI能使慢性骨髓性白血病痊愈嗎？ 01:24

（四）病人是否要一直服藥來控制病情，不能停藥？ 02:10

（五）醫生對慢性骨髓性白血病有什麼建議？ 03:12

(本短片作健康教育之用，並不可取代任何醫療診斷或治療。治療成效因人而異，如有疑問，請向專業醫療人士諮詢。)

參考資料：
1. Falchi, L., Kantarjian, H. M., Wang, X., Verma, D., Quintás-Cardama, A., O'Brien, S., … Cortes, J. E. (2013). Significance of deeper molecular responses in patients with chronic myeloid leukemia in early chronic phase treated with tyrosine kinase inhibitors. American journal of hematology, 88(12), 1024–1029. doi:10.1002/ajh.23560
2. Cortes JE, Saglio G, Kantarjian HM, et al. Final 5-year study results of DASISION: the dasatinib versus imatainib study in treatment-nviae chronic myeloid leukemia patients trial. J Clin Oncol 2016;34:2333-2340
3. Hochhaus A, Saglio G, Hughes TP, et al. Long-term benefits and risks of Goldberg, S. L., Savona, M., & Mauro, M. J. (2018). Considerations for Successful Treatment-free Remission in Chronic Myeloid Leukemia. Clinical Lymphoma Myeloma and Leukemia, 18(2), 98-105. doi:10.1016/j.clml.2017.11.006 frontline nilotinib vs imatinib for chronic myeloid leukemia in chronic phase: 5 year update of the randomized ENESTnd trial. Leukemia 2016;30:1044-1054
4. Stem Cell Transplant for Chronic Myeloid Leukemia. (n.d.). Retrieved from https://www.cancer.org/cancer/chronic-myeloid-leukemia/treating/bone-marrow-stem-cell.html
5. Talpaz, M., Mercer, J., & Hehlmann, R. (2015). The interferon-alpha revival in CML. Annals of Hematology, 94(Supplement 2), 195-207.
6. Bower, H., Björkholm, M., Dickman, P. W., Höglund, M., Lambert, P. C., & Andersson, T. M. (2016). Life Expectancy of Patients With Chronic Myeloid Leukemia Approaches the Life Expectancy of the General Population. Journal of Clinical Oncology, 34(24), 2851-2857. doi:10.1200/jco.2015.66.2866
7. Timothy P. Hughes, Carla Boquimpani, Naoto Takahashi, et al.(2018). ENESTop 144-Week Update: Long-Term Treatment-Free Remission (TFR) in Patients with Chronic Myeloid Leukemia in Chronic Phase (CML-CP) After Stopping Second-Line Nilotinib, 18, S222. doi:https://doi.org/10.1016/j.clml.2018.07.092
8. Francis J. Giles, Tamas Masszi, María Teresa Gómez Casares, et al. (2019). Treatment-free remission (TFR) following frontline (1L) nilotinib (NIL) in patients (pts) with chronic myeloid leukemia in chronic phase (CML-CP): 192-week data from the ENESTfreedom study. Journal of Clinical Oncology 2019 37:15_suppl, 7013-7013

查詢醫生資訊： https://www.finddoc.com/

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香港最全面醫療資訊影片平台，超過200位專科醫生、中醫、物理治療師、營養師等解答你的健康問題。搜尋全港各區醫生資料，即上FindDoc.com! At FindDoc, we aim to increase general public health awareness through our FindDocTV videos. Patients can make doctors’ appointments online using our platform Anytime Anywhere. FindDoc is Free and open to both patients and doctors.

看看搜尋的結果吧：

t cell lymphoma 在 T 細胞淋巴瘤之概觀與近年來治療之發展 - 內科醫學會的相關結果

關鍵詞：T 細胞淋巴瘤(T cell lymphoma). 造血幹細胞移植(Hematopoietic stem cell transplant). 組蛋白去乙醯酶抑制劑(Histone deacetylase inhibitor). ... <看更多>

t cell lymphoma 在淺談T細胞淋巴瘤的診斷與治療 - 台灣癌症防治網的相關結果

淺談T細胞淋巴瘤的診斷與治療 ... 惡性淋巴瘤，亦稱為淋巴癌，屬於淋巴細胞的異常增生。可區分為非何杰金氏淋巴瘤（non-Hodgkin's lymphoma, NHL）及何杰金 ... ... <看更多>

t cell lymphoma 在 T細胞淋巴瘤- 維基百科，自由的百科全書的相關結果

類型[編輯] · 血管中心性淋巴瘤(Angiocentric lymphoma) · 皮膚T細胞淋巴瘤(Cutaneous T cell lymphoma)：塞扎病(Sézary's disease)及蕈樣肉芽腫(Mycosis fungoides) · 間變性 ... ... <看更多>

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#1. T 細胞淋巴瘤之概觀與近年來治療之發展 - 內科醫學會

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#2. 淺談T細胞淋巴瘤的診斷與治療 - 台灣癌症防治網

淺談T細胞淋巴瘤的診斷與治療 ... 惡性淋巴瘤，亦稱為淋巴癌，屬於淋巴細胞的異常增生。可區分為非何杰金氏淋巴瘤（non-Hodgkin's lymphoma, NHL）及何杰金 ...

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Most nodal non-Hodgkin lymphomas are B-cell derived, which is in contrast to the approximately 75–85% of primary cutaneous lymphomas that are T- ...

#53. CAR T-Cell Therapy for Diffuse Large B-Cell Lymphoma

CAR T-cell therapy uses your own immune cells to fight cancer in a new way. It changes immune cells called T cells so they target tumors ...

#54. Peripheral T cell lymphoma, NOS - Pathology Outlines

Peripheral T cell lymphoma, NOS · Typically shows a diffuse (less commonly paracortical) infiltrate of small cells with subtle nuclear atypia ( ...

#55. T-Cell and NK-Cell Lymphomas | Choose the Right Test

T -cell lymphomas are a rare subset of non-Hodgkin lymphomas (NHLs) that originate from mature T-cells. NHLs that arise from natural killer (NK) cells are ...

#56. Peripheral T-Cell Lymphoma, Information, Support - CancerCare

PTCL is a rare and often fast-growing cancer that develops from white blood cells called T-lymphocytes, or T-cells. T-cells are an important ...

#57. 細胞治療於周邊T細胞淋巴瘤應用進展 - 翻轉吧癌症

周邊T細胞淋巴瘤(Peripheral T-cell lymphomas)，是一種罕見且具異質性的惡性腫瘤，屬於罕見T細胞非何杰金氏淋巴瘤(T-cell Hodgkin's lymphoma,NHL) ...

#58. Biology and Molecular Pathogenesis of Mature T-Cell ...

Abstract. Peripheral T-cell lymphomas (PTCLs) constitute a highly heterogeneous group of hematological diseases with complex clinical and ...

#59. T-Cell Lymphoblastic Leukemia/Lymphoma: Relapse 16 ...

Little information is available regarding late relapse in patients with T-lymphoblastic leukemia/lymphoma (T-LBL). Because of the aggressive nature of this ...

#60. Cutaneous T-Cell Lymphoma Presenting as Benign Dermatoses

Cutaneous T-cell lymphoma, also known as mycosis fungoides, is a malignancy of the T helper (CD4+) cells. Diagnosis is difficult early in ...

#61. Cutaneous T-Cell Lymphoma Care - Rush University System ...

The Rush Approach to Cutaneous T-Cell Lymphoma Care ... When it comes to rare cancers that are hard to diagnosis, experience matters. Dermatology and cancer ...

#62. What is Cutaneous T-Cell Lymphoma? - News Medical

Cutaneous T-cell lymphomas are a group of T-cell related cancers that mainly affect the skin. There are many different treatment options ...

#63. Peripheral T cell lymphoma, unspecified - Cancer Therapy ...

Peripheral T cell lymphoma (PTCL) is an aggressive disease that most commonly presents in patients over the age of 60 with rapidly progressive lymphadenopathy, ...

#64. Successful Treatment of Advanced Primary Cutaneous ...

Bexarotene is widely used for the treatment of early- to advanced-stage cutaneous T-cell lymphomas (CTCL), especially in European countries [1-3] ...

#65. Angioimmunoblastic T-Cell Lymphoma Mimicking Diffuse ...

Angioimmunoblastic T-cell lymphoma (AITL) is a rare, often aggressive type of peripheral T-cell lymphoma. · Cutaneous manifestations have been seen in up to 50% ...

#66. 10 things you should know about cutaneous T cell lymphoma

But in advanced stages, cutaneous T-Cell Lymphoma (CTCL), a type of non-Hodgkin lymphoma that originates in the skin, can spread through the ...

#67. Cutaneous T-Cell Lymphoma Clinic | Allegheny Health Network

It takes an experienced team to diagnose cutaneous T-cell lymphoma, and that's what you'll find at AHN. Our dermatologist works alongside a doctor who ...

#68. T-cell Lymphoma - Medscape Education

Dr. Steve Rosen discusses the exciting new agents in development and the registries that are being compiled for T-cell lymphoma.

#69. Cutaneous T-Cell Lymphoma - Department of Dermatology

... caring for patients with cutaneous T-cell lymphoma (CTCL) in Central Virginia. ... Cutaneous lymphomas are cancers of lymphocytes, a type of white blood ...

#70. Hepatosplenic T-Cell Lymphoma: What to Know - Verywell ...

Hepatosplenic T-Cell lymphoma is a very rare illness with symptoms that may include fatigue, unexplained fevers, weight loss, and abdominal ...

#71. T-Cell Lymphoma Prognosis: Outcomes and Survival Rates

There are many types of T-cell lymphoma, and each one has varying outcomes and survival rates. T-cell lymphomas are non-Hodgkin lymphomas ...

#72. Pathogenesis of Peripheral T Cell Lymphoma - Annual Reviews

Peripheral T cell lymphomas (PTCLs) are highly heterogeneous tumors, displaying distinct clinical and biological features. The pathogenesis and normal ...

#73. Adult T-Cell Leukemia/Lymphoma - Allen Press

Adult T-cell leukemia/lymphoma is a malignant lymphoproliferative neoplasm of mature T cells caused by HTLV-1, with characteristic ...

#74. 血管免疫母細胞T細胞淋巴瘤(AILT) /免疫母細胞性淋巴結病

Angioimmunoblastic T-Cell Lymphoma (AITL) Immunoblastic Lymphadenopathy Global Clinical Trials Review, H1, 2020 · 本報告概要 · 各地區的臨床實驗 ...

#75. Primary Cutaneous Gamma-Delta T-cell Lymphoma - Medical ...

Primary cutaneous gamma-delta T-cell lymphoma (PCGDTCL) is a rare form of primary cutaneous lymphoma characterized by a clonal proliferation of mature γ/δ T ...

#76. Lymphoma - Non-Hodgkin: Subtypes | Cancer.Net

These are the most common subtypes of T-cell and NK-cell lymphoma: Anaplastic large cell lymphoma, primary cutaneous type. This subtype of lymphoma only ...

#77. CAR T Cell Therapy for Lymphoma and Leukemia - University ...

... Cancer Center is proud to offer a highly specialized and highly personalized form of immunotherapy - CAR T-Cells - to treat non-Hodgkin lymphoma.

#78. T細胞淋巴瘤

皮膚T細胞淋巴瘤(Cutaneous T cell lymphoma)：塞扎病(Sézary's disease)及蕈樣肉芽腫(Mycosis fungoides); 間變性大細胞淋巴瘤(Anaplastic large-cell ...

#79. Cutaneous Lymphoma | Durham, Raleigh, North Carolina

Duke specialists treat all forms of this rare cancer, including cutaneous T-cell lymphoma (CTCL). Cutaneous lymphoma, which begins in white blood cells ...

#80. Mycosis fungoides and other cutaneous T-cell lymphomas

Primary cutaneous T-cell lymphomas (CTCLs) are a heterogeneous group of neoplasms with a wide spectrum of clinical, histological and ...

#81. Cutaneous T-Cell Lymphoma | CheckRare

Cutaneous T-cell lymphoma (CTCL) belongs to the non-Hodgkin lymphoma class of hematologic T-cell lymphoproliferative disorders.

#82. A Case of Angioimmunoblastic T-cell Lymphoma That Mimics ...

Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive malignancy with a presentation like either autoimmune diseases, drug reactions, ...

#83. Lymphoma T-cell (All variants) - Dermatology Advisor

Five distinct cutaneous T-cell lymphoma variants (ATLL, LyP, ALCL, SPTL, and CGD-TCL) are presented with how best to identify them based on their clinical ...

#84. B-Cell Lymphoma Research - Moon Shots Program - MD ...

CAR T cell therapy for B-cell lymphoma. Lymphoma/Myeloma professor Sattva Neelapu, M.D., shares how the B-Cell Lymphoma Moon Shot team is working to make the ...

#85. Stages and subtypes of cutaneous T-cell lymphoma (CTCL ...

Download scientific diagram | Stages and subtypes of cutaneous T-cell lymphoma (CTCL). (A), (B) and (C): The three main stages of mycosis fungoides (MF).

#86. Phototherapy of cutaneous T-cell lymphomas - Photochemical & ...

Cutaneous T-cell lymphomas (CTCL) are a heterogenous group of non-Hodgkin lymphomas arising in the skin. Mycosis fungoides (MF), the most common variant, ...

#87. Evaluation of cutaneous angioimmunoblastic T-cell lymphoma

Angioimmunoblastic T-cell lymphoma (AITL) accounts for 18% of peripheral T-cell lymphomas worldwide. Skin involvement occurs in up to 50% of ...

#88. Human T-lymphotropic virus type 1 - WHO | World Health ...

The virus can cause a type of cancer called adult T-cell leukaemia/lymphoma (ATL). HTLV-1 is transmitted primarily through infected bodily ...

#89. Cutaneous T-Cell Lymphoma - Dawes Fretzin Dermatology ...

Cutaneous T-cell lymphoma (CTCL) is a rare cancer. It begins in a type of white blood cell called the T-lymphocyte (T-cell). T-cells help prevent infections and ...

#90. What's new in the management of cutaneous T-cell lymphoma?

Cutaneous T-cell lymphomas (CTCL) are a heterogeneous group of disorders characterised by clonal accumulation of T lymphocytes in the skin. Mycosis fungoides ...

#91. AITL: Pathophysiology, diagnostic challenges, and current ...

Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of mature peripheral T-cell lymphoma (PTCL) that has undergone several name changes ...

#92. Single-cell profiling of cutaneous T-cell lymphoma reveals ...

Purpose: Cutaneous T cell lymphomas (CTCL), encompassing a spectrum of T-cell lymphoproliferative disorders involving the skin, ...

#93. How to differentiate this rare disease from atopic dermatitis

Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common types of cutaneous T-cell lymphoma (CTCL) [.

#94. Podcast: CAR T-cell therapy for people with diffuse large B ...

Diffuse large B-cell lymphoma is a fast-growing cancer of the lymphatic system. A new Cochrane Review from September 2021 looks at the evidence on the ...

#95. HUYABIO International Receives Regulatory Approval For ...

... Approval For Hiyasta® Monotherapy Of Peripheral T-Cell Lymphoma In Japan ... in Japan following adult T-cell leukemia/lymphoma (A TLL) ...

#96. 華上生醫新藥西達本胺恩慈治療復發或難治外周T細胞淋巴癌- 財經

... 在台灣無償提供國產西達本胺錠劑，進行超過1年8個月的恩慈治療復發或難治外周T細胞淋巴癌（R/R Peripheral T-cell lymphoma，R/R PTCL）結果。

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