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Coincidentally bought this dress after not buying clothes for 1.5 years, and was told to wear pastel blue to host the virtual launch of a new treatment option for metastatic breast cancer patients in Malaysia! It's always good to see the advent of technology on cancer treatments 🙏
#ootd #emcee #virtualevent
加護病房查房日誌20201020
今天我們來看看Pembrolizumab這個Anti-PD-1 Monoclonal Antibody，和第一線的化療藥品，用於for mismatch repair-deficient metastatic colorectal cancer病人的效果吧。
大約有3-6%的metastatic colorectal cancers (mCRCs)病人在DNA mismatch repair (dMMR)是缺乏的。這類的病人在初始系統性化療失敗後，對於immune checkpoint inhibitor immunotherapy可能有潛在的好處。
在KEYNOTE-177 trial中初步結果建議使用Pembrolizumab作為第一線的治療，比起原先第一線的化療藥品有更好的效果。對於 progression-free survival 有兩倍，甚至更高的durable objective response rates，也有較少的嚴重不良反應。
文獻來源: Andre T, Shiu K-K, Kim T-W, et al. Pembrolizumab versus chemotherapy for microsatellite instability-high/mismatch repair deficient metastatic colorectal cancer: The phase 3 KEYNOTE-177 study (abstract). J Clin Oncol 38: 2020 (suppl; abstr LBA4). Abstract available online at https://meetinglibrary.asco.org/record/186928/abstract (Accessed on June 10, 2020).
但是目前overall survival data還沒有被發表，基於目前的證據，uptodate的學者建議對於 nonoperable dMMR mCRC 的病人，第一線使用pembrolizumab單一治療比化學治療來的好。在今年六月美國Food and Drug Administration (FDA) 也核准了pembrolizumab用於第一線治療patients with unresectable or metastatic dMMR CRC.。
只是在台灣目前這樣的適應症尚未通過，目前在台灣可用於1.黑色素細胞瘤，2.非小細胞肺癌，3.典型何杰金氏淋巴瘤，4.頭頸部鱗狀細胞癌，5.泌尿道上皮癌，6. 胃癌。
3 out of 5 Malaysians don’t know what mBC means. Do you? 💗💚
When you’re diagnosed with metastatic breast cancer, it can feel like your whole life has been put on pause. Join us this October, as we share focus with the thriving Malaysian metastatic breast cancer community, giving their inspiring stories a voice.
It’s time to shed new light on the breast cancer story. Stay tuned for more videos, more stories and more resources.
Let’s talk about mBC. #UNPAUSE
#metastaticbreastcancer #breastcancer #livingbeyondbreastcancer
乳癌 －曾憲玲臨床腫瘤科專科醫生＠FindDoc.com
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（一）乳癌在香港普遍嗎？ 00:06
（二）在乳癌治療上，化療的角色是什麼？ 00:28
（三）化療感覺上很可怕，可否不採用？ 01:00
（四）化療對治療晚期乳癌有什麼好處？ 01:59
(本短片作健康教育之用，並不可取代任何醫療診斷或治療。治療成效因人而異，如有疑問，請向專業醫療人士諮詢。)
參考資料：
1. Hospital Authority. (2020). Female Breast Cancer in 2017. Retrieved from https://www3.ha.org.hk/cancereg/pdf/factsheet/2017/breast_2017.pdf
2. Moo, T. A., Sanford, R., Dang, C., & Morrow, M. (2018). Overview of Breast Cancer Therapy. PET clinics, 13(3), 339–354. https://doi.org/10.1016/j.cpet.2018.02.006
3. Cancer Research UK. (2020). When you might have chemotherapy. Retrieved from https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/chemotherapy/when-you-might-have-chemotherapy
4. Ramirez, L. Y., Huestis, S. E., Yap, T. Y., Zyzanski, S., Drotar, D., & Kodish, E. (2009). Potential chemotherapy side effects: what do oncologists tell parents?. Pediatric blood & cancer, 52(4), 497–502. https://doi.org/10.1002/pbc.21835
5. Kmietowicz, Z. (1998). Chemotherapy benefits all women with breast cancer. BMJ : British Medical Journal, 317(7162), 835. doi:http://dx.doi.org.lib-ezproxy.hkbu.edu.hk/10.1136/bmj.317.7162.835b
6. Cortes J, et al. Eribulin monotherapy versus treatment of physician’s choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomized study. Lancet 2011; 377; 914–923.
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（一）前列腺癌有多普及？00:08
（二）如何診斷是否患上前列腺癌？ 00:31
（三） 確診晚期前列腺癌的話，需如何處理？01:26
（四）有真實個案可作治療參考嗎？02:17
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(本短片作健康教育之用，並不可取代任何醫療診斷或治療。治療成效因人而異，如有疑問，請向專業醫療人士諮詢。)
1. Prostate Cancer. Centre for Health Protection . http://www.chp.gov.hk/en/content/9/25/5781.html. assessed on 22 Jun 2016
http://www3.ha.org.hk/cancereg/tc/topten.html
2. Sakr WA, Grignon DJ, Haas GP et al. Age and racial distribution of prostatic intraepithelial neoplasia. Eur Urol 1996; 30: 138–44.
3. Antonarakis ES, Eisenberger MA. Expanding treatment options for metastatic prostate cancer. N Engl J Med. 2011; 364: 2055–8.
4. Men's Health Line - Benign Prostatic Hyperplasia. (n.d.). Retrieved from https://www.chp.gov.hk/en/static/80028.html
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（一）前列腺增生等於前列腺癌？00:04
（二）如何分辨良性前列腺增生與惡性癌症？00:33
（三）確診患上前列腺癌症時，有甚麼因素需考慮？01:35
（四）前列腺癌症如擴散的話，會出現甚麼徵狀？02:23
（五）荷爾蒙治療有效嗎？02:53
1. Men's Health Line - Benign Prostatic Hyperplasia. (n.d.). Retrieved from https://www.chp.gov.hk/en/static/80028.html
2. Beer, T., Armstrong, A., Rathkopf, D., Loriot, Y., Sternberg, C., & Higano, C. et al. Enzalutamide in Metastatic Prostate Cancer before Chemotherapy. New England Journal Of Medicine, 2014; 371(5), 424-433.
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(本短片作健康教育之用，並不可取代任何醫療診斷或治療。治療成效因人而異，如有疑問，請向專業醫療人士諮詢。)
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