【用藥知多D】藥物齊打交:葉酸 vs Methotrexate?
有時候,兩種藥可能會「打交」,總是難免會有一種「既生瑜,何生亮!(《三國演義.五十七回》)」的感慨。
不過凡事一體兩面,「打交」往往可能會「鷸蚌相爭,漁人得利」。
不用問,這個漁人當然是用藥者。
例如葉酸(Folic Acid)、Methotrexate(MTX)。
首先葉酸是其中一種維生素B,其中一項功能主要在讓細胞能夠如常進行細胞分裂。
至於Methotrexate則是一種抗代謝藥(Antimetabolite),主要在妨礙DNA的合成,一般主要影響一些細胞分裂速度較快的細胞,例如癌細胞、淋巴細胞(Lymphocytes)(T細胞(T-cells)、B細胞(B-cells))、表皮細胞(Epidermal Cells),適用於治療癌症、類風濕性關節炎(Rheumatoid Arthritis, RA)、銀屑病(Psoriasis)。
至於為什麼葉酸會跟Methotrexate「打交」呢?
哦,這是因為Methotrexate同時是一種葉酸拮抗劑(Folate Antagonist),主要透過抑制體內的二氫葉酸還原酶(Dihydrofolate Reductase, DHFR)將二氫葉酸(Dihydrofolate)轉化成為四氫葉酸(Tetrahydrofolate),便可能會妨礙葉酸在體內進行活化,從而可能會誘發葉酸缺乏症。
所以理論上,要是同時服用葉酸、Methotrexate,Methotrexate便可能會消耗體內的葉酸,誘發葉酸缺乏症,而葉酸卻可能會抗衡Methotrexate的藥效。
不過實際上,服用Methotrexate治療類風濕性關節炎、幼年型類風濕性關節炎(Juvenile Rheumatoid Arthritis)、銀屑病,同時服用葉酸不但未必會妨礙Methotrexate發揮藥效,反而可能會減少Methotrexate的副作用。[1][2][3][4]
其中葉酸可能有助預防Methotrexate所誘發的肝炎[5],因為肝炎往往足以逼使用藥者停藥,所以葉酸往往可能讓更多用藥者繼續服用Methotrexate治病。
所以要是用藥者正在服用Methotrexate,偶爾可能會跟葉酸同服,目的在減少Methotrexate的副作用。
(如欲了解更多用藥資訊,歡迎看看「小小藥罐子」網誌。)
💊💊💊💊💊💊💊
BLOG➡️http://pegashadraymak.blogspot.com/
IG➡️https://www.instagram.com/pegashadraymak/
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📕📕📕📕📕📕📕
著作➡️藥事知多D、用藥知多D、藥房事件簿、家居用藥攻略(各大書店有售)
Reference:
1. Hunt PG, Rose CD, McIlvain-Simpson G, et al. The effects of daily intake of folic acid on the efficacy of methotrexate therapy in children with juvenile rheumatoid arthritis. A controlled study. J Rheumatol. 1997;24:2230-2232.
2. Duhra P. Treatment of gastrointestinal symptoms associated with methotrexate therapy for psoriasis. J Am Acad Dermatol. 1993;28:466-469.
3. Ortiz Z, Shea B, Suarez-Almazor ME, et al. The efficacy of folic acid and folinic acid in reducing methotrexate gastrointestinal toxicity in rheumatoid arthritis. A meta-analysis of randomized controlled trials. J Rheumatol. 1998;25:36-43.
4. Hoekstra M, Van Ede AE, Haagsma CJ, et al. Factors associated with toxicity, final dose, and efficacy of methotrexate in patients with rheumatoid arthritis. Ann Rheum Dis. 2003;62:423-426.
5. van Ede AE, Laan RF, Rood MJ, et al. Effect of folic or folinic acid supplementation on the toxicity and efficacy of methotrexate in rheumatoid arthritis: a forty-eight week, multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 2001;44:1515-1524.
同時也有75部Youtube影片,追蹤數超過419的網紅張偉軒小提琴 woodyviolin,也在其Youtube影片中提到,這是張偉軒小提琴老師為學生所錄製的 小步舞曲G大調 貝多芬 ~ Minuet in G - Beethoven (ベートーヴェン/34 メヌエット ト長調。 篠崎 バイオリン教本 4/5冊) 小提琴演奏示範拉奏 Violin performing 貝多芬的G大調小步舞曲是一首能見度很高的...
g eight 在 Vesper’s yoga journey Facebook 的最佳解答
Last day of #AloFlyHigh
Pincha
Thank you so much for all of you who joined us❤️❤️ sorry i will catch up with you all soon❤️
Wearing: Alo Yoga]
☁️💙New Alo Yoga Challenge Announcement!!!💙☁️
🐦 It’s a bird, ✈️ it’s a plane, it’s super Alo!🧘♀️ Come wear your super Alo outfit and join us fly high together like a superhero! 😎 Time to get our feet up and off the ground, spread our wings, explore new horizons and discover your amazing superpowers in this 8-day yoga challenge. Remember, not all superheroes wear capes and your wings already exist.. all you need to do is fly. 🙌
Challenge hashtag: #AloFlyHigh
Challenge dates: August 16-23
🌟Super hosts
@naomi.e.gally
@yogadventurebook
@acaciajadeyoga
@yogivesper
@margaritagyoga
@beahappyamy
🌟Super sponsors
Alo Yoga]
@alomoves
(I) Day 1: Locust pose ✨ If you can have any superpower in the world, what would it be?
(M) Day 2: Fallen angel ✨ Who is your favorite superhero character? (comics/movies/cartoons)
(F) Day 3: Crow or flying crow ✨ Get creative and create your own superhero name! 🦸♀️
(L) Day 4: Shoulderstand ✨Describe your ideal superhero’s sidekick
(Y) Day 5: Eight angle ✨ What is you favorite superhero slogan or famous line?
(I) Day 6:Flying lizard ✨ Who is your favorite super villain?
(N) Day 7: Boat ✨ We are all superheroes and you’re stronger than you think. What are your biggest strengths?
(G) Day 8: Yogi’s choice of Inversion or flying pose ✨ Who is your real life superhero?
g eight 在 Vesper’s yoga journey Facebook 的最佳貼文
Day 7 of #AloFlyHigh
Boat
My biggest strength is positivity❤️
Sorry I didnt like and comment on all of your lovely posts recently ❤️ I’ll catch up soon❤️ thank you for understating 🙏
Wearing: Alo Yoga]
☁️💙New Alo Yoga Challenge Announcement!!!💙☁️
🐦 It’s a bird, ✈️ it’s a plane, it’s super Alo!🧘♀️ Come wear your super Alo outfit and join us fly high together like a superhero! 😎 Time to get our feet up and off the ground, spread our wings, explore new horizons and discover your amazing superpowers in this 8-day yoga challenge. Remember, not all superheroes wear capes and your wings already exist.. all you need to do is fly. 🙌
Challenge hashtag: #AloFlyHigh
Challenge dates: August 16-23
🌟Super hosts
@naomi.e.gally
@yogadventurebook
@acaciajadeyoga
@yogivesper
@margaritagyoga
@beahappyamy
🌟Super sponsors
Alo Yoga]
@alomoves
(I) Day 1: Locust pose ✨ If you can have any superpower in the world, what would it be?
(M) Day 2: Fallen angel ✨ Who is your favorite superhero character? (comics/movies/cartoons)
(F) Day 3: Crow or flying crow ✨ Get creative and create your own superhero name! 🦸♀️
(L) Day 4: Shoulderstand ✨Describe your ideal superhero’s sidekick
(Y) Day 5: Eight angle ✨ What is you favorite superhero slogan or famous line?
(I) Day 6:Flying lizard ✨ Who is your favorite super villain?
(N) Day 7: Boat ✨ We are all superheroes and you’re stronger than you think. What are your biggest strengths?
(G) Day 8: Yogi’s choice of Inversion or flying pose ✨ Who is your real life superhero?
g eight 在 張偉軒小提琴 woodyviolin Youtube 的最佳貼文
這是張偉軒小提琴老師為學生所錄製的 小步舞曲G大調 貝多芬 ~ Minuet in G - Beethoven (ベートーヴェン/34 メヌエット ト長調。 篠崎 バイオリン教本 4/5冊) 小提琴演奏示範拉奏 Violin performing
貝多芬的G大調小步舞曲是一首能見度很高的樂曲,你甚至會在很多影音資料中找到大師公開演奏這首曲子,原本貝多芬是寫給管弦樂團演奏但是樂譜已經遺失了,可是我們還是能找到許多改編給其他樂器演奏的版本。
整個樂曲可以分成三部份:ModeratoTrioModerato1.Moderato: 由兩個 8 小節的樂段組成,總共 16 小節。曲調的特點是重複但優雅的八分音符和十六分音符連奏模式。
2.Trio: 特點是流暢、不間斷的八分音符。
3.Moderato:樂曲返回開頭的旋律,但這次不會再反覆。
Ludwig van Beethoven's Minuet in G major, No. 2 is a composition originally written for orchestra, but was lost and only an arrangement for piano could be found. It has become very popular.The minuet is in incipient ternary form, A-A-B-A
the three parts are:
ModeratoTrioModerato
The Moderato section features a melody, marked legato (to play in a smooth, even style without noticeable breaks between the notes).
The trio section features non-stop eighth notes . It starts with an eight-measure modulating passage repeated once and moves on to another eight-measure passage that ends in the tonic, and is also repeated once.
The last section, which is Moderato also, is a repeat of the first section, but without the repeat. It is that which makes the piece an incipient ternary song form: A-A-B-A.
元々は管弦楽曲として1795年に作曲され、1796年にウィーンで出版された。しかし現存するのはピアノ編曲版のみである。これは《ピアノのための6つのメヌエット 第2部》というタイトルで出版されたが、「第2部」と書かれているのは同年に作曲された《2つのヴァイオリンとバスのためのメヌエット》WoO9(但しベートーヴェンの真作かどうかは確証されていない)を意識してのことではないかとされている。
➡️ If you like my video, please support me by making a donation. I really appreciate your generous support!
支持我的音樂影片,透過小額捐款讓我有更多資源去提升製作,謝謝!
➡️Paypal: https://paypal.me/ViolinChang
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小提琴相關的資訊與教學歡迎點選以下連結:
➡️教學網站(website):https://reurl.cc/4R6LWR
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楊欣展 台中 鋼琴老師/鋼琴伴奏老師
網站:https://reurl.cc/b53Wao
#篠崎#小提琴演奏 #小提琴示範 #小提琴教學
g eight 在 踢萬8IG8A8Y Youtube 的最佳貼文
#88barsremix #大嘻哈時代 #乞丐ceo
最近覺得88Bars有點屌然後決定做一個自己的版本,其實我也不確定自己到底有沒有內定,反正就是先報名再說
在 StreetVoice 上面聽:
https://streetvoice.com/papetone/songs/638467/
追蹤我的 IG:
https://www.instagram.com/onemoretimebabywu/
888S Credit:
作曲Composed by 踢萬8ig8a8y
作詞Lyrics by 踢萬8ig8a8y
製作人Producer by 薑母鴨ginger duck
編曲Beats Arrangement by 薑母鴨ginger duck
混音Mixing by章湘柏
母帶後期Mastering by章湘柏
錄音室Recording Studio Nora Says諾拉說
設計Logo Design by Demi.C
影片剪輯 Editing by 楊策
888S Lyrics:
萬
插卡進 ATM,
餘額好像沒有變
Yeah I’m trained to bring game,
華語嘻哈音樂圈還是硬了點 (硬拉)
BIGGIE 萬 my band, (my band)
Just When things seems the same
and the whole scene is lame,
Goddamn 還是討厭下雨天 (OSN)
Show no respect, so relaxed,
go too fast, toast to that (Clink)
8IG8A8Y 八十八個 BARS 霸的話語權
“No Flocking” like Kodak Black (On they ass)
Fuck it 下局見, 風格太平太侷限
Na mean? I need change like PiNkChAiN
太依戀曬衣鏈 What’s my name?
@ONEMORETIMEBABY 再一遍 (踢萬)
February Twenty Eight, 進大嘻哈時代掙專輯費
三票當選【窮】到四腳朝天, 身價還沒天價但直接
翻一倍 (double up)
Drinking 西西里 Coffee 『Let Me 嘻犀里』
Mini 晉級到 MTV 裡
沈浸在進擊的信義區,
忠言逆耳說實話我有聽進去 (listen)
了無牽掛 just wanna, work on my album
千里馬 "PONY" 還沒開喝就先掛
先發制人,水到渠成 (每幹拎)
Rhyme scheme so brilliant,
萬 in a billion, 專情的明理人,
Told y’all Imma finished them (On GOD)
鑽新的 bars, shine like 鑽金的卡, 硬底子 Indie 的 rock
講心裡的話,穿金戴銀 (Nah) 是該清醒了吧?
沈睡已久最純粹野獸為何會困獸之鬥?
剃刀蔣那 part, 太嘻哈實在 Imma keep that in mind
無限 看齊感激 fo sho (That's right)
HAHA I don’t really care how you feel, everywhere I go
All Star, Hall Of Fame 116, always in the field
獅子星座 Leo 王者爭霸
肉弱強食從此先發, 不是種子真假?
What the fuck happened to Hip Hop?
金價萬夫莫敵,一匹黑馬,思維 gain-up (My 思維)
Know pain Know game huh?
Spitting fire 太嗨了 higher than Higher Brothers
我的 flow 五花八門
喜歡 started from the bottom
Mo money mo problems, 火侯只開了八成
Now I got options
請叫我木柵人
What’s popping?
Reping Taipei City 捍衛我的家人
我的 freestyle 不好說不好不會加分
我的 attitude so awesome
燒肉粽燒口燙, 就像我的貨,roll up son 不誇張
遇強則強,這是我的命
8IG8A8Y 巨嬰活體的 meme
牛年行大運收拾玻璃心,demo 已經錄了太多首你聽
噴 flows, money in, 收進收銀機 (Ching ching)
Drinking Ice Tea 到 6AM in the morning
文字當兇器
Love me or hate me, don’t give a fuck about you
還有你的抨擊
恭喜如果有 “Baby Fat” 幫你拍拍手 (拍手聲)
Hashtag 我 #曬北鼻challenge 有在用 IG 都可以參加 though (Okay)
我不需要拍影片,我知道會有人拍我
曾太多向左向右,生態濁,畢竟深愛過深愛過深愛過
My flows never lazy 從不怠惰 I know
我身高187 所以你看我都要抬頭,94不是一個 idol
Got the key 可以開鎖
Suicide doors 麻將輸了太多,主很愛我 (Lord)
讓我們保持聯絡就算到四點多 (FO)
【窮】,【4PM】, 【Burning】, Make Secens
把真實故事寫進歌裡每一天
Fuck you pay me 請你給錢
Get rich or die trying 就像 50 CENT (GGG G-UNIT)
萬
888S
g eight 在 運動營養師 楊承樺 Youtube 的最佳貼文
內容製作產出不易,你的 按讚訂閱分享 是支持我們的動力。
(發1篇影片要看超過20幾篇研究文獻再整理出最摘要建議,不幫我追蹤,按讚,分享出去,
安內甘丟 ~ XD )
168間歇性斷食,運動營養師我也早已實行多年,但過去自己用的配法沒有說太多是因為一直在等研究證據出現來支持我的觀點(畢竟有一分證據才說一分話)。
以前已經有些研究發現若只作斷食而不搭配運動容易掉肌肉,
但這次有更新的研究發現支持下可以來跟大家說:你可以改成168間歇性斷食 搭配 重訓 就可避免掉肌肉還能減脂,但該怎做呢?
很簡單今天影片來教大家怎麼安排會更好,並用全家便利商店的 蛋白纖食餐
來示範說明。
對影片中研究有興趣的,我把文獻來源放在最底下。
附註:本次討論針對都是沒有疾病的成年人為對象,若在生病中或有慢性疾病像是糖尿病,或特殊族群例如:學齡青少年、兒童、孕婦、年長者、飲食障礙者、腸胃不適者等等,都不是今天討論的對象。若有其他您不確定的狀況,請先諮詢過您的醫師或營養師意見。
--
#個人運動飲食安排有疑問者建議請先洽詢運動營養師 #168 #斷食。
#增肌減脂 #飲食顧問服務 #營養講座 #運動營養
#促進運動表現飲食顧問服務 #減重 #減肥 #運動營養師 #競技運動營養師 #營養品顧問 #拼pin小教室
#北市大運科所 #SportsNutrition #SportsDietitian #SportsScience
#Inbody570 #統一陽光豆漿 #全家健康志向 #蛋白纖食餐 #超級大麥 #運動應援
想看更多營養知識?快按下「訂閱」及小鈴鐺,一有新影片,馬上通知你!
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文獻來源:
Lowe, D. A., Wu, N., Rohdin-Bibby, L., Moore, A. H., Kelly, N., Liu, Y. E., ... & Weiss, E. J. (2020). Effects of time-restricted eating on weight loss and other metabolic parameters in women and men with overweight and obesity: the TREAT randomized clinical trial. JAMA internal medicine, 180(11), 1491-1499.
Tinsley, G. M., Moore, M. L., Graybeal, A. J., Paoli, A., Kim, Y., Gonzales, J. U., ... & Cruz, M. R. (2019). Time-restricted feeding plus resistance training in active females: a randomized trial. The American journal of clinical nutrition, 110(3), 628-640.
Stratton, M. T., Tinsley, G. M., Alesi, M. G., Hester, G. M., Olmos, A. A., Serafini, P. R., ... & VanDusseldorp, T. A. (2020). Four weeks of time-restricted feeding combined with resistance training does not differentially influence measures of body composition, muscle performance, resting energy expenditure, and blood biomarkers. Nutrients, 12(4), 1126.
Moro, T., Tinsley, G., Bianco, A., Marcolin, G., Pacelli, Q. F., Battaglia, G., ... & Paoli, A. (2016). Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males. Journal of translational medicine, 14(1), 1-10.