賀!👏 👏 👏
本院前院長、翁啟惠院士榮獲2021年威爾許化學獎(Welch Award in Chemistry) ,也是首位獲得此獎項的華人科學家。
此獎表彰得獎人在化學研究的重要貢獻。翁啟惠院士長年鑽研於化學生物及醣分子科學研究,是全球首位發展多醣體自動化合成、以酵素方法量產醣分子及醣蛋白的科學家,他所發明的「程式化一鍋式反應法」,讓醣分子能在實驗室裡快速合成,是第一個自動化合成多醣體的化學方法,他的酵素法也是目前唯一可大量而快速合成寡醣的方法。同時,他也持續將醣科學應用於癌症疫苗、醣晶片、醣探針、對抗病毒及細菌之藥物研究等。
威爾許基金會董事會主席Carin Barth說:「威爾許基金會的任務是透過化學研究的突破來改善他人生活,翁博士已經以此為目標深深耕數十年。他不僅在化學和生物領域研究上有革命性的進展,他的方法也將有助未來新藥和疫苗研發」。
威爾許化學獎由威爾許基金會(Robert A. Welch Foundation)設置,旨在促進和鼓勵基礎化學研究,彰顯化學研究造福人類社會的貢獻。該獎項於化學領域擁有盛名,自1972年設立至今,每年頒發給1至2名,截至上屆已有54位科學家獲此殊榮。包含翁院士在內,目前僅2位亞裔科學家獲獎。
‧2021威爾許化學獎:https://welch1.org/awards/welch-award-in-chemistry
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The Welch Foundation, one of the nation’s largest sources of private funding for basic chemical research, has announced that Professor Chi-Huey Wong is the 2021 recipient of the prestigious Robert A. Welch Award in Chemistry. Dr. Wong is an influential leader who has made numerous discoveries in the fields of synthetic chemistry and chemical biology that have benefited humankind. With this award, he is being recognized for his development of new methods for the synthesis of complex carbohydrates and glycoproteins and the elucidation of carbohydrate-mediated biological recognition associated with disease progression.
#翁啟惠 #醣科學
同時也有10000部Youtube影片,追蹤數超過2,910的網紅コバにゃんチャンネル,也在其Youtube影片中提到,...
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disease progression 在 中央研究院 Academia Sinica Facebook 的最讚貼文
🔔#你的肝包太多油了嗎❗❗
🎯#脂肪肝 是國人常見的肝臟疾病,早期沒有明顯症狀,長期下來卻可能演變為肝炎、肝硬化或肝癌,迄今仍缺乏有效治療藥物💊。本院生物化學研究所 #陳瑞華 特聘研究員團隊發現一種操控細胞自噬(autophagy)的新機制,✅經動物實驗證明能 #抑制脂肪肝形成。
#什麼是細胞自噬
細胞自噬是細胞的主要資源回收機制,可消除細胞內的老舊廢物,或選擇性地清除細胞內的過多脂肪。
👨🔬👩🔬研究團隊發現一個名為UBE3C的泛素接合酶與一個名為TRABID的去泛素酶,共同調控細胞自噬因子VPS34,以達到細胞內的恆定狀態 👇
1⃣UBE3C藉分枝型泛素化修飾VPS34蛋白質,導致VPS34降解(degradation),被分解為小片段,#抑制 細胞自噬功能。
2⃣TRABID去除VPS34的泛素化修飾,使其不被降解,#促進 細胞自噬。
團隊以高脂飼料餵食小鼠誘發產生脂肪肝後,發現小鼠肝細胞內 #TRABID表現量下降,#無法啟動肝臟細胞的自噬作用。當這些小鼠被注射以腺病毒載體攜帶的TRABID基因,四週後從細胞切片觀察,✅肝臟油脂含量明顯減少,✅能抑制脂肪肝形成。
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陳瑞華表示,「🎉本研究對於脂肪肝的治療提供新契機,若能研發出提高TRABID表現或其活性的 #藥物,則可能阻斷脂肪肝的形成,進而預防肝功能異常、肝臟發炎等相關疾病。」
🌏研究成果於本(110)年2月發表在國際期刊《自然通訊》(Nature Communications)。
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Fatty liver is a prevalent liver disease in Taiwan and worldwide and is associated with obesity, diabetes and cardiovascular diseases. Although fatty liver is normally asymptomatic, its progression can lead to hepatitis, cirrhosis, and even liver cancer. The research team of Dr. Ruey-Hwa Chen at Institute of Biological Chemistry identifies a novel autophagy regulatory mechanism and a potential of preventing fatty liver progression by manipulating this mechanism. The study has recently been published on February 26 in Nature Communications.
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📌論文全文:https://www.nature.com/articles/s41467-021-21715-1
📌新聞稿:https://www.sinica.edu.tw/ch/news/6826
📌Press Release: https://www.sinica.edu.tw/en/news/6826
#生物化學研究所 #中研院研究 #細胞自噬 #Fattyliver
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disease progression 在 KAKA LAM 嘉嘉 Facebook 的最佳解答
TOP5 MONTHLY FAVORITES MAR 2021
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disease progression 在 18. Disease Progression Modeling and Subtyping, Part 1 的美食出口停車場
MIT 6.S897 Machine Learning for Healthcare, Spring 2019Instructor: David SontagView the complete course: ... ... <看更多>