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#1. A Programmable Dual-RNA–Guided DNA Endonuclease ...
Abstract · 1 Cas9 is a DNA endonuclease guided by two RNA molecules. · 2 Cas9 uses two nuclease domains to cleave the two strands in the target ...
#2. A programmable dual-RNA-guided DNA ... - PubMed
The dual-tracrRNA:crRNA, when engineered as a single RNA chimera, also directs sequence-specific Cas9 dsDNA cleavage. Our study reveals a family ...
#3. (PDF) A Programmable Dual-RNA-Guided DNA ...
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity. June 2012; Science 337(6096):816-21.
#4. CRISPR debuted 10 years ago, in a paper hardly anyone ...
That paper, “A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity,” has now been cited by more than 15,000 ...
#5. A Primer for “A Programmable Dual-RNA-Guided DNA ...
Return to Article Details Examining CRISPR-Cas9: A Primer for “A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity.
#6. A Programmable Dual-RNA–Guided DNA Endonuclease in ...
Abstract: Ditching Invading DNA Bacteria and archaea protect themselves from invasive foreign nucleic acids through an RNA-mediated adaptive immune system ...
#7. A Tool for Genome Editing - Nobel Prize
Jinek, M., et al., A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science, 2012. 337(6096): p. 816-21.
#8. A Programmable Dual-RNA-Guided DNA ... - Addgene
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity. Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E Science.
#9. RNA-programmed genome editing in human cells - eLife
Type II CRISPR immune systems in bacteria use a dual RNA-guided DNA endonuclease, Cas9, to cleave foreign DNA at specific sites.
#10. تويتر \ MC HAMMER على تويتر: "A programmable dual ...
A programmable dual RNA-guided DNA endonuclease in adaptive bacterial immunity # ... CRISPR/Cas systems provide bacteria and archaea with adaptive immunity ...
#11. Jinek, M., Doudna, J., Charpentier, E., et al. (2012) A ...
Jinek, M., Doudna, J., Charpentier, E., et al. (2012) A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity. Science, 337, 816-821.
#12. CRISPR, 10 Years On: Learning to Rewrite the Code of Life
... title she and her colleagues had chosen for the study: “A Programmable Dual RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity.”.
#13. A programmable dual-RNA-guided DNA ... - OneSearch
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.(RESEARCH ARTICLE)(Author abstract)(Report)-article.
#14. Jennifer Doudna - Google Scholar
A programmable dual -RNA–guided DNA endonuclease in adaptive bacterial immunity. M Jinek, K Chylinski, I Fonfara, M Hauer, JA Doudna, E Charpentier.
#15. AAAS Fellow因CRISPR發展而獲2020諾貝爾化學獎
... 年於《Science》發表了他們獲得諾貝爾獎的CRISPR 研究–A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity。
#16. October 31, 2019 - Editas Medicine
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science. 2012 Aug 17;337(6096):816-21. doi: ...
#17. article Paper topic : A Programmable Dual-RNA-Guided DNA...
article Paper topic : A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity. by jinek et al. QUESTIONS.
#18. A programmable dual-RNA-guided DNA endonuclease in ...
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Jinek M et al. Science. 2012 Aug 17; 337(6096):816-821.
#19. A Programmable Dual-RNA-Guided DNA ... - Quizlet
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity - INCOMPLETE ... how to we use CRISPR to not just cut viral DNA but any DNA?
#20. 以內生性U6 啟動子發展Pichia pastoris CRISPR/Cas9 系統
A programmable dual -RNA–guided DNA endonuclease in adaptive bacterial immunity. Science, 337(6096), 816-821. 12. Sternberg, S. H., Redding, S., Jinek, M., ...
#21. A programmable dual RNA-guided DNA endonuclease in ...
CRISPR/Cas systems provide bacteria and archaea with adaptive immunity against viruses and plasmids by using crRNAs to guide the silencing of invading ...
#22. Programmable DNA scissors found for bacterial immune system
... in the journal Science describing this work titled "A programmable dual RNA-guided DNA endonuclease in adaptive bacterial immunity.
#23. RNA-guided gene targeting - Jena Bioscience
(2012) A programmable dual-RNA-guided, DNA endonuclease in adaptive bacterial immunity. Science 337(6096):816. [2] Wang et al. (2016) CRISPR/Cas9 in Genome ...
#24. Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 ...
Cpf1 is a CRISPR-associated two-component RNA-programmable DNA nuclease ... Almost all archaea and many bacteria achieve adaptive immunity ...
#25. Gene editing by CRISPR–Cas - Nature
From its origins as a bacterial immune system, CRISPR–Cas has been developed ... Programmable dual-RNA-guided DNA endonuclease in adaptive ...
#26. [PDF] The widespread IS200/IS605 transposon family ...
—DJ A widespread class of transposon-encoded RNA-guided nucleases show ... Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity.
#27. CRISPR Cas 9 Nuclease RNA-guided Genome Editing
First, the gRNA requires 17–21 bases of RNA-to-DNA homology, ... A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity. Science.
#28. CRISPR gene editing | PNAS
M Jinek, et al., A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337, 816–821 (2012).
#29. CRISPR Timeline | Broad Institute
The discovery of the CRISPR-Cas microbial adaptive immune system and its ... A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
#30. Martin JINEK - Google 學術搜尋
A programmable dual -RNA–guided DNA endonuclease in adaptive bacterial immunity. M Jinek, K Chylinski, I Fonfara, M Hauer, JA Doudna, E Charpentier.
#31. CRISPR‐Cas9: how research on a bacterial RNA‐guided ...
... Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E (2012) A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
#32. Dynamic RNA Nanotechnology Enters the CRISPR Toolbox
... Fonfara, I.; Hauer, M.; Doudna, J. A.; Charpentier, E. A Programmable dual-RNA-guided DNA Endonuclease in Adaptive Bacterial Immunity.
#33. PatCite - The Lens - Free & Open Patent and Scholarly Search
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Jinek Martin et al. Science (New York, N.Y.) (28 Jun 2012).
#34. Genetic scissors: at the cutting-edge of life - WIPO
... and Doudna and others publish their research in Science under the title A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity.
#35. CRISPR/Cas9, a decade of genome editing tools to fix the DNA
Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
#36. CRISPR : le Nobel, enfin… | médecine/sciences
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity ... complex mediates specific DNA cleavage for adaptive immunity in bacteria.
#37. Making the cut with PAMless CRISPR-Cas enzymes
A programmable dual-RNA–guided DNA endonuclease in adaptive bacterial immunity. Science. (2012) ; DNA interrogation by the CRISPR RNA-guided endonuclease Cas9 ...
#38. Excitation et crispations autour de CRISPR : lorsque la réalité ...
Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
#39. Jennifer Doudna and Emmanuelle Charpentier's Experiment ...
Doudna, and Emmanuelle Charpentier. "A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity." Science 337 (2012): 816–21 ...
#40. save - Sci-Hub
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity. Science, 337(6096), 816–821. doi:10.1126/science.1225829.
#41. 基因編輯教母珍妮佛道納訪台演講，細述CRISPR-Cas9 系統
A programmable dual -RNA-guided DNA endonuclease in adaptive bacterial immunity. RNA-programmed genome editing in human cells. New CRISPR-Cas ...
#42. CRISPR genome editing reference library - LubioScience
“A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity”. Science. 337(6096): 816–821. Bibcode:2012Sci...337..816J.
#43. A Programmable Dual-RNA—Guided DNA Endonuclease in ...
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems provide bacteria and archaea with adaptive immunity ...
#44. Programmable DNA Scissors Found for Bacterial Immune ...
... in the journal Science describing this work titled “A programmable dual RNA-guided DNA endonuclease in adaptive bacterial immunity.
#45. CRISPR Office Hours with Jennifer Doudna - Synthego
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. The paper that made CRISPR what it is today!
#46. CRISPR-Cas - metabion
CRISPR-Cas are a natural immunity mechanism developed by bacteria and ... A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity.
#47. Newly discovered systems expand the CRISPR-Cas toolkit
Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity. Science 337, 816–821. doi:10.1126/science.1225829. Jinek, M., Jiang, F., ...
#48. Phylogeny of Cas9 determines functional exchangeability of ...
The CRISPR-Cas-derived RNA-guided Cas9 endonuclease is the key element ... dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
#49. LP CRISPR-Cas9 Genome Editing - DOE Office of Science
“A Programmable Dual-RNA – Guided DNA Endonuclease in Adaptive Bacterial Immunity.” Science 337(6096): 816-821. DOI: 10.1126/science.1225829.
#50. CRISPR - iGEM Parts
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337, 816-821. Cong, L., et al. (2013). Multiplex genome engineering ...
#51. A programmable dual-rna–guided dna endonuclease in ...
Información del artículo A programmable dual-rna–guided dna endonuclease in adaptive bacterial immunity.
#52. Undergraduate CRISPR Journal Club
Presenter, Vindhya Kilaru, Undergraduate journal club student leader. Paper. A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity ...
#53. RNA-Guided Genome Editing of Mammalian Cells
The microbial CRISPR-Cas adaptive immune system can be harnessed to ... A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
#54. How CRISPR Revolutionized Science - Bio-Rad Antibodies
CRISPR and Cas9 genes form an adaptive immune system to help bacteria ... A programmable dual-RNA-guided DNA endonuclease in adaptive ...
#55. A Programmable Dual-RNA-Guided DNA Endonuclease in ...
Science , 2012, Vol.337(6096), p.816-820 ,. A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity. Comprobar servicios disponibles ...
#56. CRISPR–Cas9 Structures and Mechanisms - Annual Reviews
... bacterial clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated (Cas) systems employ the dual RNA–guided DNA endonuclease ...
#57. RNA-guided CRISPR-Cas technologies for genome-scale ...
From its discovery as an adaptive bacterial and archaea immune system, ... E. A programmable dual-RNA-guided DNA endonuclease in adaptive ...
#58. Programmable RNA Complex Could Speed Genome Editing ...
A programmable dual RNA-guided DNA endonuclease in adaptive bacterial immunity. Science (2012) (June 28, Ahead of print). *Equal contribution.
#59. Biology, Mechanism and Applications of CRISPR-Cas ...
Biology, Mechanism and Applications of CRISPR-Cas Immune System ... A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
#60. Comprehensive deletion landscape of CRISPR-Cas9 ...
et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337, 816–821 ...
#61. aaf5573.full-2.pdf - McGovern Institute for Brain Research
M. Jinek et al., A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337,. 816–821 (2012). doi: 10.1126/science.1225829; ...
#62. CRISPR Makes It to the Clinic
These sequences serve part of the bacterial immune system, a genetic memory ... A programmable dual-RNA-guided DNA endonuclease in adaptive ...
#63. History of CRISPR - Inscripta®
No discovery is made in isolation · [1] Jinek, Martin, et al. “A programmable dual-RNA – guided DNA endonuclease in adaptive bacterial immunity.” Science ...
#64. CRISPR-associated endonuclease Cas9 (IPR028629) - InterPro
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E. Science ...
#65. Jennifer A. Doudna | Molecular and Cell Biology
The CRISPR bacterial adaptive immune system ... A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
#66. Virologie - CRISPR-Cas: the bacterial immunity that supports ...
CRISPR-Cas: the bacterial immunity that supports diagnostic in virology Volume ... E. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial ...
#67. CRISPR–Cas9-mediated genome editing and guide RNA ...
CRISPR–Cas9 is an RNA-guided DNA endonuclease system in which Cas9 ... dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
#68. Publications - Doudna Lab
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E Science ...
#69. The CRISPR-Cas Mechanism for Adaptive Immunity and ...
Bacterial and archaeal CRISPR-Cas systems offer adaptive immune protection ... A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive ...
#70. A Programmable Dual-RNA–Guided DNA Endonuclease in ...
Question: A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity. 1)What is the larger question that the set of experiments are ...
#71. RNA-guided editing of bacterial genomes using CRISPR-Cas ...
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337, 816-821 (2012). (8.) Deveau, H., Garneau, J.E. & Moineau, ...
#72. Trans-activating crRNA - Wikipedia
^ Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E (2012). "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity".
#73. RNA-guided gene targeting - Cellco
(2012) A programmable dual-RNA-guided, DNA endonuclease in adaptive bacterial immunity. Science 337(6096):816. [2] Wang et al. (2016) CRISPR/Cas9 in Genome ...
#74. CRISPR-Cas9 | New Tool for Genome Editing - Genetics
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity. Science 337: 816–821. This paper describes the adaptation of the bacterial ...
#75. Publications - Transomic.
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity. Science 17 August 2012: Vol. 337 no. 6096 pp. 816-821. Jinek, M et al.
#76. CRISPR-Cas9 Specificity: Taming Off-target Mutagenesis
A programmable dual-RNA–guided DNA endonuclease in adaptive bacterial immunity. Science 337, 816. Li, et al. (2013). Heritable gene targeting in the mouse ...
#77. Professor Jennifer Doudna | Biographical summary
... J. A., Charpentier E., et al, 'A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity', Science, 337/6097 (2012), 816-21.
#78. 細菌の適応免疫におけるプログラム可能な二重RNA誘導DNA ...
細菌の適応免疫におけるプログラム可能な二重RNA誘導DNAエンドヌクレアーゼ. A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity.
#79. A New and Possibly More Effective Method for Editing Genomes
Reference: “A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity” by Martin Jinek, Krzysztof Chylinski, ...
#80. Enter CRISPR: Jennifer Doudna's Autobiographical ...
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science. 2012;337(6096):816-21. DOI: 10.1126/science.1225829. Doudna J, ...
#81. Programmable Removal of Bacterial Strains by Use of ...
CRISPR-Cas systems are RNA-directed adaptive immune systems in many bacteria ... A programmable dual-RNA-guided DNA endonuclease in adaptive ...
#82. Cas9 protein - The School of Biomedical Sciences Wiki
Cas9 is shown to be useful in bacterial gene manipulation. ... programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
#83. C2c1-sgRNA Complex Structure Reveals RNA
dual -RNA-guided DNA endonuclease (Shmakov et al., 2015). ... The role of C2c1 in bacterial immunity and its potential.
#84. The CRISPR web page - CNB
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing ... A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
#85. A Programmable Dual-RNA–Guided - Ross Nickels - Prezi
CRISPR/ CRISPR associated repeats have evolved in bacteria and archaea as a ... Cas9 endonuclease can be programmed with guide RNA engineered as a single ...
#86. A Programmable Dual-RNA–Guided DNA ... - Puriney
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity. 08/18/2012 by puriney. Clustered regularly interspaced short palindromic ...
#87. A programmable dual-RNA-guided DNA ... - Coggle
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity (Jinek et al., 2015) · What mechanism facilitates Cas9 function in type II CRISPR/ ...
#88. CRISPR: A Word Processor for Editing the Genome - iBiology
This Youreka Science video explores how a group of scientists made a major breakthrough in understanding the bacterial immune response, called the ...
#89. Into the Future with CRISPR Technology with Jennifer Doudna
CRISPR-Cas9, an RNA - guided enzyme with remarkable abilities to recognize and cleave DNA, operates by mechanisms that both explain its ...
#90. Journal Club | Pierre Billon lab
RNA -guided DNA insertion with CRISPR-associated transposases published in Science ... CRISPR was discovered as a prokaryotic adaptive immune system to fight ...
#91. Efficient Cas9 multiplex editing using unspaced sgRNA arrays ...
(2012) A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science., 337, 816– 821. Lau, C.H. & Suh, Y. ... (2017) In ...
#92. Grüne Gentechnik: Tod vom Acker? | Science Cops Folge 51
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity (Science, 2012) · Yang et al.: Contributions of Zea mays ...
#93. Genome Stability: From Virus to Human Application
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 2012;337(6096):816–21. [5] Smith J, et al.
#94. CRISPR: Biology and Applications - 第 96 頁 - Google 圖書結果
A programmable dual - RNA - guided DNA endonuclease in adaptive bacterial immunity . Science 337 : 816–821 . 14. Koonin EV , Makarova KS , Zhang F. 2017.
#95. Gene Therapy for Viral Infections - 第 91 頁 - Google 圖書結果
Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
#96. Animal Cell Biotechnology: In Biologics Production
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 2012;337:816-21. Horvath P, Barrangou R. CRISPR/Cas, the immune ...
#97. The Use of CRISPR/cas9, ZFNs, TALENs in Generating ...
Functional genomics, proteomics, and regulatory DNA analysis in isogenic ... A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
a programmable dual-rna-guided dna endonuclease in adaptive bacterial immunity 在 Into the Future with CRISPR Technology with Jennifer Doudna 的美食出口停車場
CRISPR-Cas9, an RNA - guided enzyme with remarkable abilities to recognize and cleave DNA, operates by mechanisms that both explain its ... ... <看更多>